CAJ | 학술논문

　　目的对比观察正五聚蛋白3（PTX3）在高血压不同心功能状况和射血分数的患者中的变化，并探讨其临床意义。方法连续选取武汉市武昌医院门诊或心内科、老年科诊治的156例初诊原发性高血压患者为研究对象，先依据心脏超声结果分为两组：单纯高血压（PH）组42例和高血压心脏病（HHD）组114例。后者又依据左心室射血分数及有无心功能衰竭症状分为HHD无心力衰竭（NHF）亚组34例、射血分数正常 HHD 心力衰竭（HFNEF）亚组36例和射血分数降低 HHD 心力衰竭（HFREF）亚组44例。抽取静脉血检测所有患者的PTX3、超敏C反应蛋白（hs-CRP）和N端脑钠肽前体（NT-proBNP）并予以比较、分析。结果 PH组PTX3、hs-CRP、NT-proBNP水平明显低于 HHD组，差异有统计学意义（P＜0．01）。 HHD组中PTX3、hs-CRP、NT-proBNP水平则从NHF亚组到 HFNEF亚组，再到 HFREF亚组依次升高，两两比较差异均有统计学意义（P＜0．01）。PTX3水平与hs-CRP水平呈正相关（r＝0．573，P＜0．01），与 NT-proBNP水平呈正相关（r＝0．452，P＜0．01）。结论PTX3在 HHD患者中随病情进展逐渐增高，可以作为监测高血压患者心功能及射血分数变化的一项生物学指标，从而在协助H HD左心室射血分数正常心力衰竭诊断上发挥一定的作用。
　　목적대비관찰정오취단백3（PTX3）재고혈압불동심공능상황화사혈분수적환자중적변화，병탐토기림상의의。방법련속선취무한시무창의원문진혹심내과、노년과진치적156례초진원발성고혈압환자위연구대상，선의거심장초성결과분위량조：단순고혈압（PH）조42례화고혈압심장병（HHD）조114례。후자우의거좌심실사혈분수급유무심공능쇠갈증상분위HHD무심력쇠갈（NHF）아조34례、사혈분수정상 HHD 심력쇠갈（HFNEF）아조36례화사혈분수강저 HHD 심력쇠갈（HFREF）아조44례。추취정맥혈검측소유환자적PTX3、초민C반응단백（hs-CRP）화N단뇌납태전체（NT-proBNP）병여이비교、분석。결과 PH조PTX3、hs-CRP、NT-proBNP수평명현저우 HHD조，차이유통계학의의（P＜0．01）。 HHD조중PTX3、hs-CRP、NT-proBNP수평칙종NHF아조도 HFNEF아조，재도 HFREF아조의차승고，량량비교차이균유통계학의의（P＜0．01）。PTX3수평여hs-CRP수평정정상관（r＝0．573，P＜0．01），여 NT-proBNP수평정정상관（r＝0．452，P＜0．01）。결론PTX3재 HHD환자중수병정진전축점증고，가이작위감측고혈압환자심공능급사혈분수변화적일항생물학지표，종이재협조H HD좌심실사혈분수정상심력쇠갈진단상발휘일정적작용。
Objective To explore the changes of pentraxin-3(PTX-3) in the normal left ventricular ejection fraction of patients with heart failure in patients of hypertention heart disease and discuss its clinical significance .Methods 156 outpatients or inpa-tients of department of Cardiovascular ,Geriatrics ,firstly diagnosed primary hypertension ,of Wuchang hospital in WuHan City were selected as research objects .the subjects were divided into two groups based on the results of echocardiography :simple primary hy-pertension(PH) group(42 cases)and hypertention heart disease(HHD) group(114 cases) ,the latter group were divided into with-out syptom of heart failure-NHF subgroup(34 cases) ,with normal left ventricular ejection fraction and syptom of heart failure-HF-NEF subgroup(36 cases)and with decreasing left ventricular ejection fraction and symptoms of heart failure-HFREF subgroup(44 cases) .To measure and analysis the level of PTX-3 ,high sensitivity c-reactive protein (hs-CRP) ,N-terminal pro-brain natriuretic peptide(NT-proBNP) in the blood plasm .Results Compared to HHD group ,the level of PTX3 ,hs-CRP ,NT-proBNP was lower (P<0 .01) .The level of PTX3 ,hs-CRP ,NT-proBNP was increased from NHF group ,HFNEF group to HFREF group ,significance differences were seen between each group .The level of PTX3 was positively correlated to hs-CRP(r=0 .573 ,P<0 .01) ,and was positively correlated to NT-proBNP(r=0 .452 ,P<0 .01) .Conclusion PTX3 increases with the progress of patients with primary hypertention heart disease ,It can be used as a biomarker of heart failure in the patients of hypertention heart disease with normal left ventricular ejetion fraction .