CAJ | 학술논문

　　目的探讨乌司他丁（UTI）心肌保护作用临床影响因素。方法选择急性心肌梗死（AMI）患者120例，在溶栓、抗休克、纠正心功能衰竭等常规诊疗措施基础上，给予U T I治疗，按发病后给药时机不同分为A组（12 h内给药）、B组（12 h后给药），各组再分小剂量（250 kU ）、中等剂量（500 kU ）、大剂量（1000 kU ）组各20例，治疗1周后分别行心脏超声检查，测定左室收缩末期内径（LVESD）、左室舒张末期内径（LVEDD）、左室射血分数（LVEF）、每搏输出量（SV），肌酸激酶同工酶（CK-MB）峰浓度。结果大剂量、12 h内给药者心功能改善程度及CK-MB峰浓度下降程度较小剂量、12 h后给药者明显（P＜0．05）。结论同种病因，给药时机、给药剂量的不同可影响UTI的临床疗效。
　　목적탐토오사타정（UTI）심기보호작용림상영향인소。방법선택급성심기경사（AMI）환자120례，재용전、항휴극、규정심공능쇠갈등상규진료조시기출상，급여U T I치료，안발병후급약시궤불동분위A조（12 h내급약）、B조（12 h후급약），각조재분소제량（250 kU ）、중등제량（500 kU ）、대제량（1000 kU ）조각20례，치료1주후분별행심장초성검사，측정좌실수축말기내경（LVESD）、좌실서장말기내경（LVEDD）、좌실사혈분수（LVEF）、매박수출량（SV），기산격매동공매（CK-MB）봉농도。결과대제량、12 h내급약자심공능개선정도급CK-MB봉농도하강정도교소제량、12 h후급약자명현（P＜0．05）。결론동충병인，급약시궤、급약제량적불동가영향UTI적림상료효。
Objective Toexploreinfluencingfactorsoftheulinastatin(UTI)onmyocardialprotection.Methods 120casesofa-cute myocardial infarction(AMI) patients were given UTI at the base of conventional treatment for heart failure like thrombolysis , resistance to shock .The patients were divided into group A (within 12 hours) and group B (after 12 hours) ,and than each group was divided into subdivision small dose (250 kU) ,medium dose (500 kU) ,large dose (1 000 kU) groups .The patients were re-ceived echocardiogram examination ,determination of left ventricular contraction end-diastolic diameter(LVESD ,LVEDD) testing , left ventricular ejection fraction(LVEF) testing ,each stroke output(SV) ,peak concentration of creatine kinase isoenzyme(CK-MB) after treated for one week .Results Compared with the small dose and after 12 hours groups ,large dose and within 12 hours group caused an increase of cardiac function and density loss of CK-MB peak concentration (P<0 .05) .Conclusion The same cause of myocardial injury ,dose and administration timing will affect the clinical efficacy of UTI .