CAJ | 학술논문

　　目的探讨研究支气管哮喘患者在治疗前、治疗后的气道反应性。方法选择2009年9月-2012年11月云浮市新兴县人民医院收治的轻度支气管哮喘患者50例和中度支气管哮喘50例为研究对象，对患者均给予临床治疗，治疗方案为氟替卡松/沙美特罗吸入，其中轻度哮喘患者剂量为50/100 mg，每日2次；中度哮喘患者剂量为50/250 mg。观察治疗前、治疗后2个月、3个月两组患者的气道反应性。结果轻度哮喘和中度哮喘患者在治疗2个月后，其症状积分、第一秒钟用力呼气量占预计值百分比(FEV 1%)和最大呼吸流量占预计值百分比(PEF%)均有明显改善，差异有统计学意义（P＜0.05）；两组患者在治疗3个月与治疗2个月的症状积分、FEV 1%及PEF%比较差异无统计学意义（P＞0.05）。结论支气管哮喘患者在治疗2个月内会有明显的气道反应性改变，但是在3个月后会维持在一定水平，需要医生引起重视，调整药物治疗方案。
　　목적탐토연구지기관효천환자재치료전、치료후적기도반응성。방법선택2009년9월-2012년11월운부시신흥현인민의원수치적경도지기관효천환자50례화중도지기관효천50례위연구대상，대환자균급여림상치료，치료방안위불체잡송/사미특라흡입，기중경도효천환자제량위50/100 mg，매일2차；중도효천환자제량위50/250 mg。관찰치료전、치료후2개월、3개월량조환자적기도반응성。결과경도효천화중도효천환자재치료2개월후，기증상적분、제일초종용력호기량점예계치백분비(FEV 1%)화최대호흡류량점예계치백분비(PEF%)균유명현개선，차이유통계학의의（P＜0.05）；량조환자재치료3개월여치료2개월적증상적분、FEV 1%급PEF%비교차이무통계학의의（P＞0.05）。결론지기관효천환자재치료2개월내회유명현적기도반응성개변，단시재3개월후회유지재일정수평，수요의생인기중시，조정약물치료방안。
Objective To investigate the study of bronchial asthma patients to give reference before treatment, diagnosis and treatment of airway hyperresponsiveness after treatment for patients with bronchial asthma. Methods From September 2009 to November 2012 in our hospital with mild bronchial asthma patients 50 cases, 50 cases of moderate bronchial asthma were chosen for the study, all patients were given clinical treatment,treatment of lfuticasone/salmeterol, inhaled dose of mild asthma is 50/100 mg, 2 times a day;50/250 mg dose for patients with moderate asthma. before treatment, after treatment 2 month, 3 months, airway hyperresponsiveness of two groups were observed. Results After 2 months of treatment, the symptom score, FEV 1%and PEF%in mild asthma and moderate asthma patients had improved signiifcantly, P<0.05;symptoms scores,FEV 1%and PEF%in two groups after 2 months of treatment and 3 months of treatment had no obvious difference , P>0.05. Conclusion Patients with bronchial asthma within 2 months of treatment there will be signiifcant change of airway responsiveness , but after three months it will remain at a level that requires a doctor to pay attention to adjust drug treatment programs.