中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
16期
122-123
,共2页
高危型人乳头瘤病毒%不典型鳞状细胞%管理
高危型人乳頭瘤病毒%不典型鱗狀細胞%管理
고위형인유두류병독%불전형린상세포%관리
High risk human papilloma virus%Atypical squamous cells%Administration
目的：探讨高危型人乳头瘤病毒(HR HPV)检测在临床管理宫颈不典型鳞状细胞中的作用。方法：采用第二代杂交捕获法(HC2)对268例宫颈细胞学检查为诊断意义不明的不典型鳞状细胞(ASCUS)的患者进行 HR HPV 检测，同时行阴道镜检查及病理活检，分析高危型人乳头瘤病毒感染与宫颈病变关系及临床中对 ASCUS 患者的管理。结果：268例患者中，病理组织学为炎症121例(45.2%)，宫颈上皮内瘤变(CIN)Ⅰ97例(36.19%)，CINⅡ27例(10.07%)， CINⅢ19例(7.09%)，宫颈浸润癌4例(1.49%)，其中HR HPV阳性率53.36%(143例)，CIN及以上病变在阳性组中检出率82.00%(118例)，明显高于阴性组23.86%(29例)，与CIN及宫颈癌有明显相关性，HPV阳性组ASCUS病例的CIN检出率明显高于HPV阴性组，差异有统计学意义(P＜0.01)。结论：HR HPV检测对分流ASCUS中的高危人群有重要的临床意义，对阳性者做进一步的阴道镜检查与活检是明确诊断的较好路径，阴性者可随访观察。
目的：探討高危型人乳頭瘤病毒(HR HPV)檢測在臨床管理宮頸不典型鱗狀細胞中的作用。方法：採用第二代雜交捕穫法(HC2)對268例宮頸細胞學檢查為診斷意義不明的不典型鱗狀細胞(ASCUS)的患者進行 HR HPV 檢測，同時行陰道鏡檢查及病理活檢，分析高危型人乳頭瘤病毒感染與宮頸病變關繫及臨床中對 ASCUS 患者的管理。結果：268例患者中，病理組織學為炎癥121例(45.2%)，宮頸上皮內瘤變(CIN)Ⅰ97例(36.19%)，CINⅡ27例(10.07%)， CINⅢ19例(7.09%)，宮頸浸潤癌4例(1.49%)，其中HR HPV暘性率53.36%(143例)，CIN及以上病變在暘性組中檢齣率82.00%(118例)，明顯高于陰性組23.86%(29例)，與CIN及宮頸癌有明顯相關性，HPV暘性組ASCUS病例的CIN檢齣率明顯高于HPV陰性組，差異有統計學意義(P＜0.01)。結論：HR HPV檢測對分流ASCUS中的高危人群有重要的臨床意義，對暘性者做進一步的陰道鏡檢查與活檢是明確診斷的較好路徑，陰性者可隨訪觀察。
목적：탐토고위형인유두류병독(HR HPV)검측재림상관리궁경불전형린상세포중적작용。방법：채용제이대잡교포획법(HC2)대268례궁경세포학검사위진단의의불명적불전형린상세포(ASCUS)적환자진행 HR HPV 검측，동시행음도경검사급병리활검，분석고위형인유두류병독감염여궁경병변관계급림상중대 ASCUS 환자적관리。결과：268례환자중，병리조직학위염증121례(45.2%)，궁경상피내류변(CIN)Ⅰ97례(36.19%)，CINⅡ27례(10.07%)， CINⅢ19례(7.09%)，궁경침윤암4례(1.49%)，기중HR HPV양성솔53.36%(143례)，CIN급이상병변재양성조중검출솔82.00%(118례)，명현고우음성조23.86%(29례)，여CIN급궁경암유명현상관성，HPV양성조ASCUS병례적CIN검출솔명현고우HPV음성조，차이유통계학의의(P＜0.01)。결론：HR HPV검측대분류ASCUS중적고위인군유중요적림상의의，대양성자주진일보적음도경검사여활검시명학진단적교호로경，음성자가수방관찰。
Objective:To explore the effect of high risk human papillomavirus detection in clinical management of patients with cervical atypical squamous cells.Methods:268 cases with atypical squamous cells(ASCUS) whose diagnosis were unclear with cervical cytology were given HR HPV detection with the second generation of hybrid capture(HC2),at the same time,they were given colposcopy and biopsy.We analyzed the relationship of high-risk HPV infection with cervical lesions and the management of ASCUS patients in clinic.Results:In 268 cases,histopathology was inflammation in 121 cases(45.2%),97 cases(36.19%) were CIN Ⅰ,27 cases(10.07%) were CIN Ⅱ,19 cases(7.09%) were CIN Ⅲ,4 cases(1.49%) were invasive cervical cancer.Among them, the positive rate of HR HPV was 53.36%(143 cases).The positive detection rate of CIN and above lesions in the positive group was 82% (118 cases).It was significantly higher than that in the negative group of 23.86% (29 cases),and had a significant correlation with CIN and cervical cancer.The positive rate of CIN of ASCUS cases in the HPV positive group was significantly higher than that in HPV negative group,and the difference was statistically significant(P<0.01).Conclusion:HR HPV detection has important clinical significance for shunting high-risk groups in ASCUS.It is a better path for clear diagnosis of positive patients with colposcopy and biopsy.Negative people can be observed.
