中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
16期
19-20
,共2页
糖尿病周围神经病变%联合疗法%疗效
糖尿病週圍神經病變%聯閤療法%療效
당뇨병주위신경병변%연합요법%료효
Diabetic peripheral neuropathy%Combination therapy%Curative effect
目的：观察依帕司他、前列地尔联合α-硫辛酸治疗糖尿病周围神经病变的疗效及安全性。方法：收治糖尿病周围神经病变患者120例，随机分为对照组和治疗组，各60例。对照组静滴前列地尔10μg，1次/日，口服依帕司他50mg，3次/日；治疗组在对照组基础上增加静滴α-硫辛酸600mg，1次/日。两组均3周1疗程，观察治疗前后患者的临床症状及肌电图改善情况。结果：治疗组、对照组总有效率分别为93.3%、68.3%，两者差异有统计学意义(P＜0.01)。两组治疗后正中神经和腓总神经的运动神经传导速度(MCV)和感觉神经传导速度(SCV)较治疗前均有明显改善(P＜0.05)，治疗组较对照组改善更明显(P＜0.01)。两组均未见明显的不良反应。结论：依帕司他、前列地尔联合α-硫辛酸治疗糖尿病周围神经病变疗效优于依帕司他联合前列地尔，并且无明显不良反应。
目的：觀察依帕司他、前列地爾聯閤α-硫辛痠治療糖尿病週圍神經病變的療效及安全性。方法：收治糖尿病週圍神經病變患者120例，隨機分為對照組和治療組，各60例。對照組靜滴前列地爾10μg，1次/日，口服依帕司他50mg，3次/日；治療組在對照組基礎上增加靜滴α-硫辛痠600mg，1次/日。兩組均3週1療程，觀察治療前後患者的臨床癥狀及肌電圖改善情況。結果：治療組、對照組總有效率分彆為93.3%、68.3%，兩者差異有統計學意義(P＜0.01)。兩組治療後正中神經和腓總神經的運動神經傳導速度(MCV)和感覺神經傳導速度(SCV)較治療前均有明顯改善(P＜0.05)，治療組較對照組改善更明顯(P＜0.01)。兩組均未見明顯的不良反應。結論：依帕司他、前列地爾聯閤α-硫辛痠治療糖尿病週圍神經病變療效優于依帕司他聯閤前列地爾，併且無明顯不良反應。
목적：관찰의파사타、전렬지이연합α-류신산치료당뇨병주위신경병변적료효급안전성。방법：수치당뇨병주위신경병변환자120례，수궤분위대조조화치료조，각60례。대조조정적전렬지이10μg，1차/일，구복의파사타50mg，3차/일；치료조재대조조기출상증가정적α-류신산600mg，1차/일。량조균3주1료정，관찰치료전후환자적림상증상급기전도개선정황。결과：치료조、대조조총유효솔분별위93.3%、68.3%，량자차이유통계학의의(P＜0.01)。량조치료후정중신경화비총신경적운동신경전도속도(MCV)화감각신경전도속도(SCV)교치료전균유명현개선(P＜0.05)，치료조교대조조개선경명현(P＜0.01)。량조균미견명현적불량반응。결론：의파사타、전렬지이연합α-류신산치료당뇨병주위신경병변료효우우의파사타연합전렬지이，병차무명현불량반응。
Objective:To explore the efficacy and safety of epalrestat,alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy.Methods:120 cases with diabetic peripheral neuropathy were selected.They were randomly divided into the control group and the treatment group with 60 cases in each.The control group were treated with alprostadil 10μg for intravenous drip,1 time/day,epalrestat 50mg orally,3 times/day.The treatment group added alpha lipoic acid 600mg for intravenous drip,1 time/day.In the two groups,1 course of treatment was 3 weeks.We observed the clinical symptoms before and after treatment and EMG in patients with improvement.Results:The total efficiency of the treatment group and the control group were 93.3% and 68.3% respectively.The difference was statistically significant(P<0.01).After treatment,the motor nerve conduction velocity(MCV) and sensory nerve conduction velocity(SCV) of the median nerve and common peroneal nerve of the two groups were improved significantly(P<0.05).Compared with the control group,the treatment group was improved more obviously(P<0.01).There were no obvious adverse reactions in two groups.Conclusion:Curative effect of epalrestat,alprostadil combined with alpha lipoic acid in the treatment of diabetic peripheral neuropathy is better than that of epalrestat combined with alprostadil,and there is no obvious adverse reaction.
