CAJ | 학술논문

目前研究认为,SLC5A8是一种新的候选肿瘤抑制基因,在人类的甲状腺癌、食管癌、胃癌、结肠癌和急性髓系白血病中表达降低或缺失.该基因位于人类染色体12q13-23编码蛋白,属于Na+/葡萄糖共转运蛋白家族成员,是Na+耦联的转运短链脂肪酸、乳酸、烟酸和碘化物的载体.其外显子1的GPG岛的甲基化及组蛋白去乙酰化可使SLC5A8基因表达沉默,促进肿瘤的发生.SLC5A8表达的转运体的所有底物中,丁酸、丙酸和丙酮酸的功能是作为组蛋白脱乙酰基酶抑制剂,它们可以介导多种肿瘤细胞的凋亡,可能为其抑制肿瘤的机制.
목전연구인위,SLC5A8시일충신적후선종류억제기인,재인류적갑상선암、식관암、위암、결장암화급성수계백혈병중표체강저혹결실.해기인위우인류염색체12q13-23편마단백,속우Na+/포도당공전운단백가족성원,시Na+우련적전운단련지방산、유산、연산화전화물적재체.기외현자1적GPG도적갑기화급조단백거을선화가사SLC5A8기인표체침묵,촉진종류적발생.SLC5A8표체적전운체적소유저물중,정산、병산화병동산적공능시작위조단백탈을선기매억제제,타문가이개도다충종류세포적조망,가능위기억제종류적궤제.
Current research suggests that SLC5A8 is a new candidate tumor-suppressor gene whose expression is reduced or deficient in human thyroid cancer,esophageal cancer,gastric cancer,colon cancer and acute myeloid leukemia.The gene is in human chromosomes 12q13-23,and encoding proteins that belongs to the members of the family of sodium/glucose transporters.It is sodium-coupled carrier that transfer short chain fatty acid,lactic acid,nicotinic acid and iodide.The exon 1 of GPG island methylation and histone acetylation can make SLC5A8 gene express silenced and promote the occurrence of tumor.of all transporter substrates of SLC5A8 expresses,butyrate,propionate and pyruvate function as histone deacetylase inhibitors and can be mediated apoptosis of many kinds of tumor cells,which may be the mechanism of inhibiting tumor.