江西医药
江西醫藥
강서의약
JIANGXI MEDICAL JOURNAL
2014年
4期
288-290
,共3页
2 型糖尿病%瑞舒伐他汀%高甘油三酯血症
2 型糖尿病%瑞舒伐他汀%高甘油三酯血癥
2 형당뇨병%서서벌타정%고감유삼지혈증
Type 2 diabetes mellitus%Rosuvastatin%Hyper triglyceridemia
目的：观察瑞舒伐他汀对2型糖尿病患者合并脂代谢紊乱治疗的疗效与安全性。方法对38例2型糖尿病合并脂代谢紊乱患者进行为期8周的瑞舒伐他汀治疗，并比较治疗前、治疗后的TC、TG、HDL-C、LDL-C等指标的变化，分析其对2型糖尿病合并脂代谢紊乱各组分的疗效及安全性。结果经瑞舒伐他汀治疗8周后，与治疗前相比，TC、TG、LDL-C水平均分别下降（21.50±19.75）%、（39.20±20.50）%、（16.98±33.18）%（P＜0.01或P＜0.05），而HDL-C则升高（14.20±20.71）%（P＜0.05）。治疗期间，除1例ALT轻度升高外，无咽炎、肌痛、头痛和肝肾功能损害等不良反应发生。结论瑞舒代他汀能较好地纠正2型糖尿病患者合并的血脂代谢紊乱，尤其是TC、TG、LDL-C的降低效果明显，且安全性良好。
目的：觀察瑞舒伐他汀對2型糖尿病患者閤併脂代謝紊亂治療的療效與安全性。方法對38例2型糖尿病閤併脂代謝紊亂患者進行為期8週的瑞舒伐他汀治療，併比較治療前、治療後的TC、TG、HDL-C、LDL-C等指標的變化，分析其對2型糖尿病閤併脂代謝紊亂各組分的療效及安全性。結果經瑞舒伐他汀治療8週後，與治療前相比，TC、TG、LDL-C水平均分彆下降（21.50±19.75）%、（39.20±20.50）%、（16.98±33.18）%（P＜0.01或P＜0.05），而HDL-C則升高（14.20±20.71）%（P＜0.05）。治療期間，除1例ALT輕度升高外，無嚥炎、肌痛、頭痛和肝腎功能損害等不良反應髮生。結論瑞舒代他汀能較好地糾正2型糖尿病患者閤併的血脂代謝紊亂，尤其是TC、TG、LDL-C的降低效果明顯，且安全性良好。
목적：관찰서서벌타정대2형당뇨병환자합병지대사문란치료적료효여안전성。방법대38례2형당뇨병합병지대사문란환자진행위기8주적서서벌타정치료，병비교치료전、치료후적TC、TG、HDL-C、LDL-C등지표적변화，분석기대2형당뇨병합병지대사문란각조분적료효급안전성。결과경서서벌타정치료8주후，여치료전상비，TC、TG、LDL-C수평균분별하강（21.50±19.75）%、（39.20±20.50）%、（16.98±33.18）%（P＜0.01혹P＜0.05），이HDL-C칙승고（14.20±20.71）%（P＜0.05）。치료기간，제1례ALT경도승고외，무인염、기통、두통화간신공능손해등불량반응발생。결론서서대타정능교호지규정2형당뇨병환자합병적혈지대사문란，우기시TC、TG、LDL-C적강저효과명현，차안전성량호。
Objective To explore the clinical effect and security of Rosuvastatin for type 2 diabetes mellitus with lipid metabolismdisorder. Methods 38 type 2 diabetes mellitus cases with lipid metabolismdisorder were treated by rosuvastatin for 8 weeks. The TC,TG,HDL-C,LDL-C for pretherapy and post-treatment were compared. The clinical effect and security for the pa-tients with type 2 diabetes mellitus and lipid metabolismdisorder were analyzed. Results The levels of TC,TG,LDL-C were lower than those prior treatment (21.50±19.75)%,(39.20±20.50)%,(16.98±33.18)%(P<0.01 or P<0.05);The levels of HDL-C were higher than of prior treatment (14.20±20.71)%(P<0.05). Except one case were with ALT increased,there were no pharyngitis, myalgia, headache,renal function damage. Conclusion It can improve the disorder for the patients with type 2 diabetes mellitus and lipid metabolismdisorder by Rosuvastatin,especially for the reduce of TC,TG,LDL-C,and it has good safety.
