中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
11期
10-11
,共2页
脐带因素%胎儿%生长发育
臍帶因素%胎兒%生長髮育
제대인소%태인%생장발육
Umbilical cord factors%Fetus%Growth and development
目的：探讨脐带血临床指标评价胎儿生长发育情况的临床应用价值。方法选取该院出生的新生儿96例，根据胎龄以及出生体重百分位数的关系将所有新生儿分为小于胎龄儿（SGA）组、适于胎龄儿（AGA）组以及大于胎龄儿（LGA）组，测量新生儿的出生体重、身长、头围、胎盘重量以及体质指数（BMI），同时采用放射免疫法检测新生儿的脐血瘦素、胰岛素样生长因子Ⅰ（IGF-Ⅰ）以及生长激素(GH)，并分析与胎儿生长发育的关系。结果 LGA组新生儿脐带血瘦素、IGF-Ⅰ以及GH水平分别为（1.58±0.08） ng/mL、（4.52±0.98） ng/mL、（35.78±12.49） ng/mL，明显高于AGA组和SGA组新生儿，随着新生儿体重的增加，新生儿的身长、头围、胎盘重量以及BMI也会随着增加.新生儿脐带血瘦素、IGF-Ⅰ以及GH水平与体重、身长、头围、胎盘重量以及BMI均呈正相关。结论瘦素、胰岛素样生长因子Ⅰ（IGF-Ⅰ）以及生长激素(GH)在胎儿生长发育过程中发挥着重要的调节作用，作为评价胎儿生长发育状况及营养状态具有重要的临床应用价值。
目的：探討臍帶血臨床指標評價胎兒生長髮育情況的臨床應用價值。方法選取該院齣生的新生兒96例，根據胎齡以及齣生體重百分位數的關繫將所有新生兒分為小于胎齡兒（SGA）組、適于胎齡兒（AGA）組以及大于胎齡兒（LGA）組，測量新生兒的齣生體重、身長、頭圍、胎盤重量以及體質指數（BMI），同時採用放射免疫法檢測新生兒的臍血瘦素、胰島素樣生長因子Ⅰ（IGF-Ⅰ）以及生長激素(GH)，併分析與胎兒生長髮育的關繫。結果 LGA組新生兒臍帶血瘦素、IGF-Ⅰ以及GH水平分彆為（1.58±0.08） ng/mL、（4.52±0.98） ng/mL、（35.78±12.49） ng/mL，明顯高于AGA組和SGA組新生兒，隨著新生兒體重的增加，新生兒的身長、頭圍、胎盤重量以及BMI也會隨著增加.新生兒臍帶血瘦素、IGF-Ⅰ以及GH水平與體重、身長、頭圍、胎盤重量以及BMI均呈正相關。結論瘦素、胰島素樣生長因子Ⅰ（IGF-Ⅰ）以及生長激素(GH)在胎兒生長髮育過程中髮揮著重要的調節作用，作為評價胎兒生長髮育狀況及營養狀態具有重要的臨床應用價值。
목적：탐토제대혈림상지표평개태인생장발육정황적림상응용개치。방법선취해원출생적신생인96례，근거태령이급출생체중백분위수적관계장소유신생인분위소우태령인（SGA）조、괄우태령인（AGA）조이급대우태령인（LGA）조，측량신생인적출생체중、신장、두위、태반중량이급체질지수（BMI），동시채용방사면역법검측신생인적제혈수소、이도소양생장인자Ⅰ（IGF-Ⅰ）이급생장격소(GH)，병분석여태인생장발육적관계。결과 LGA조신생인제대혈수소、IGF-Ⅰ이급GH수평분별위（1.58±0.08） ng/mL、（4.52±0.98） ng/mL、（35.78±12.49） ng/mL，명현고우AGA조화SGA조신생인，수착신생인체중적증가，신생인적신장、두위、태반중량이급BMI야회수착증가.신생인제대혈수소、IGF-Ⅰ이급GH수평여체중、신장、두위、태반중량이급BMI균정정상관。결론수소、이도소양생장인자Ⅰ（IGF-Ⅰ）이급생장격소(GH)재태인생장발육과정중발휘착중요적조절작용，작위평개태인생장발육상황급영양상태구유중요적림상응용개치。
Objective To investigate the clinical application value of umbilical cord blood indexes for evaluating the fetal growth and development. Methods 96 cases of neonates born in our hospital were selected and divided into small for gestational age (SGA) group, appropriate for gestational age (AGA) group and large for gestational age (LGA) group. The birth weight, length, head circumference, placental weight, and body mass index (BMI) of the newborns were measured. Umbilical cord blood leptin, insulin-like growth factor Ⅰ(IGF-I) and growth hormone (GH) were detected by radioimmunoassay, and the relationship between which and fetal growth and development was analyzed. Results The umbilical cord blood leptin, IGF-I and GH levels of the newborns in LGA group was(1.58±0.08) ng/mL, 4.52±0.98 ng/mL, (35.78±12.49) ng/mL, which was significantly higher than that of the new-borns in AGA group and SGA group, respectively. Along with the increase of birth weight, neonatal length, head circumference, placental weight and BMI of the newborns would increase, too. Neonatal umbilical cord blood leptin, IGF-I and GH levels and body weight, length, head circumference, placental weight, and BMI were positively correlated. Conclusion Leptin, insulin-like growth factorⅠ(IGF-I) and growth hormone (GH) play an important role in the regulation of fetal growth and development process, which have important clinical value in the evaluation of fetal growth and development condition and nutritional status.
