中外医疗
中外醫療
중외의료
CHINA FOREIGN MEDICAL TREATMENT
2014年
11期
6-7
,共2页
阿尔茨海默病%临床表现%诊断%治疗
阿爾茨海默病%臨床錶現%診斷%治療
아이자해묵병%림상표현%진단%치료
Alzheimer's disease%Clinical manifestation%Diagnosis%Treatment
目的：探讨阿尔茨海默病的临床诊治。方法选取该院2010年1月-2012年1月间收治的阿尔茨海默病患者31例为观察组，回顾性分析其临床资料；选取同期在该院进行健康体检的老年人31例为对照组，用MRI检测两组研究对象的侧脑室体积，对比2010-2011年侧脑室变化情况。结果65岁以上的患者较65岁以下的患者比例显著升高（P<0.01），性别之间无统计学差异；临床主要表现为记忆力下降；简易智能量表评分均低于23分，其中重度痴呆占多数；超1/4的患者具有家族阳性史；2年内观察组患者左侧、右侧和双侧侧脑室体积明显大于正常组（P<0.01）；观察组患者侧脑室体积随时间的推移呈明显递增趋势。结论该病的早期诊治仍为临床工作的重点，基因诊断和治疗可能具有较好的效果，各侧侧脑室体积动态变化情况可能是阿尔茨海默病患者的特征性影像学表现之一，可用于临床判断疾病的严重程度。
目的：探討阿爾茨海默病的臨床診治。方法選取該院2010年1月-2012年1月間收治的阿爾茨海默病患者31例為觀察組，迴顧性分析其臨床資料；選取同期在該院進行健康體檢的老年人31例為對照組，用MRI檢測兩組研究對象的側腦室體積，對比2010-2011年側腦室變化情況。結果65歲以上的患者較65歲以下的患者比例顯著升高（P<0.01），性彆之間無統計學差異；臨床主要錶現為記憶力下降；簡易智能量錶評分均低于23分，其中重度癡呆佔多數；超1/4的患者具有傢族暘性史；2年內觀察組患者左側、右側和雙側側腦室體積明顯大于正常組（P<0.01）；觀察組患者側腦室體積隨時間的推移呈明顯遞增趨勢。結論該病的早期診治仍為臨床工作的重點，基因診斷和治療可能具有較好的效果，各側側腦室體積動態變化情況可能是阿爾茨海默病患者的特徵性影像學錶現之一，可用于臨床判斷疾病的嚴重程度。
목적：탐토아이자해묵병적림상진치。방법선취해원2010년1월-2012년1월간수치적아이자해묵병환자31례위관찰조，회고성분석기림상자료；선취동기재해원진행건강체검적노년인31례위대조조，용MRI검측량조연구대상적측뇌실체적，대비2010-2011년측뇌실변화정황。결과65세이상적환자교65세이하적환자비례현저승고（P<0.01），성별지간무통계학차이；림상주요표현위기억력하강；간역지능량표평분균저우23분，기중중도치태점다수；초1/4적환자구유가족양성사；2년내관찰조환자좌측、우측화쌍측측뇌실체적명현대우정상조（P<0.01）；관찰조환자측뇌실체적수시간적추이정명현체증추세。결론해병적조기진치잉위림상공작적중점，기인진단화치료가능구유교호적효과，각측측뇌실체적동태변화정황가능시아이자해묵병환자적특정성영상학표현지일，가용우림상판단질병적엄중정도。
Objective To explore the clinical diagnosis and treatment of Alzheimer's disease. Methods 31 cases of patients with Alzheimer's disease admitted in our hospital from January, 2010 to January, 2012 were selected as the observation group, and the clinical data of them were analyzed retrospectively. And 31 cases of elderly people underwent healthy examination in our hospital during the same period were selected as the control group. MRI was used to detect lateral ventricular volume of the two groups of patients, and the lateral ventricle changes between 2010 and 2011 were compared. Results The proportion of patients over 65 years with the disease was significantly higher than that of the patients below the age of 65 (P<0.01), but there was no statistically significant difference between that of male patients and female patients; the main clinical manifestations were memory deteriora-tion; MMSE scores were lower than 23 points, severe dementia were in the majority; over 1/4 patients with positive family history. During the two years, the left ventricular volume, the right ventricular volume and bilateral ventricle volume of the patients in the observation group were obviously bigger than those of the patients in the control group (P<0.01);the lateral ventricle volume of the patients in the observation group showed an increasing trend over time. Conclusion Early diagnosis and treatment of this disease is still the focus of clinical work. Gene diagnosis and gene therapy may have a better effect. Changes of ventricular volume in each side may be the performance of image features, and can be used for clinical diagnosis of disease severity.
