CAJ | 학술논문

【目的】探讨白细胞介素-24（IL-24）及血管内皮生长因子C（VEGF-C）在宫颈浸润鳞癌组织中的表达及意义。【方法】采用免疫组织化学技术检测在正常宫颈组织（A组）、宫颈上皮内瘤样病变（B组）、宫颈浸润鳞癌组织（C组）中IL-24及VEGF-C的表达，分析其意义。【结果】A组IL-24高表达率显著高于B、C组，且B组显著高于C组；A组VEGF-C高表达率显著低于B、C组，且B组显著低于C组，其差异均有统计学意义（ P＜0．05）。宫颈鳞癌中IL-24的表达随着临床分期进展而降低，而与年龄，病理分级及间质浸润深度无关（ P ＞0．05）；宫颈癌淋巴结无转移组IL-24表达显著高于有淋巴结转移组（ P ＜0．05）；宫颈鳞癌中V EG F-C在不同临床分期及病理分级中表达无明显差异（ P ＞0．05），但淋巴结转移组的VEGF-C表达显著高于无淋巴结转移组（ P ＜0．05）。宫颈浸润鳞癌组IL-24与VEGF-C阳性表达率呈负相关（ P ＜0．05）。【结论】IL-24在正常宫颈组织，CIN及宫颈鳞癌中的阳性表达逐级降低且宫颈鳞癌淋巴有转移组几乎为阴性，而V EG F-C在其中的表达逐级增强且宫颈鳞癌淋巴有转移组高表达，两者呈明显的负相关，推断IL-24与VEGF-C可能与宫颈鳞癌的进展及淋巴转移有关。
【목적】탐토백세포개소-24（IL-24）급혈관내피생장인자C（VEGF-C）재궁경침윤린암조직중적표체급의의。【방법】채용면역조직화학기술검측재정상궁경조직（A조）、궁경상피내류양병변（B조）、궁경침윤린암조직（C조）중IL-24급VEGF-C적표체，분석기의의。【결과】A조IL-24고표체솔현저고우B、C조，차B조현저고우C조；A조VEGF-C고표체솔현저저우B、C조，차B조현저저우C조，기차이균유통계학의의（ P＜0．05）。궁경린암중IL-24적표체수착림상분기진전이강저，이여년령，병리분급급간질침윤심도무관（ P ＞0．05）；궁경암림파결무전이조IL-24표체현저고우유림파결전이조（ P ＜0．05）；궁경린암중V EG F-C재불동림상분기급병리분급중표체무명현차이（ P ＞0．05），단림파결전이조적VEGF-C표체현저고우무림파결전이조（ P ＜0．05）。궁경침윤린암조IL-24여VEGF-C양성표체솔정부상관（ P ＜0．05）。【결론】IL-24재정상궁경조직，CIN급궁경린암중적양성표체축급강저차궁경린암림파유전이조궤호위음성，이V EG F-C재기중적표체축급증강차궁경린암림파유전이조고표체，량자정명현적부상관，추단IL-24여VEGF-C가능여궁경린암적진전급림파전이유관。
[Objective]To explore the expression of interleukin-24(IL-24) and vascular endothelial growth fac-tor-C(VEGF-C) in invasive cervical squamous carcinoma(CSC) and its significance .[Methods]Immunohistochemi-cal method was used to detect the expression of IL-24 and VEGF-C in normal cervix(group A) ,cervical intraepi-thelial neoplasia(CIN ,group B) and invasive cervical squamous carcinoma(group C) .The significance was ana-lyzed .[Results] The expression rate of IL-24 in group A was markedly higher than that in group B and group C , and that in group B was also markedly higher than that in group C .The expression rate of VEGF-C in group A was markedly lower than that in group B and group C ,and that in group B was markedly lower than that in group B ,and there was significant difference( P<0 .05) .The expression of IL-24 in CSC was decreased with the devel-opment of clinical stage ,but was not correlated with age ,pathological stage and interstitial invasion depth ( P>0 . 05) .The expression of IL-24 in cervical cancer group without lymph node metastasis was markedly higher than that in cervical cancer group with lymph node metastasis ( P <0 .05) .There was no significant difference in the expression of VEGF-C in different clinical stage and pathological grade of CSC ( P >0 .05) ,but the expression of VEGF-C in lymph node metastasis group was markedly higher than that in no lymph node metastasis group ( P<0 .05) .The expression of IL-24 in invasive CSC group was negatively related with VEGF-C( P<0 .05) .[Conclu-sion]The expression of IL-24 in normal cervix tissue ,CIN and CSC is gradually decreased ,and it is negative in CSC group with lymph node metastasis .The expression of VEGF-C in CSC is increased gradually and higher in CSC group with lymph node metastasis .There is obviously negative correlation between IL-24 and VEGF-C .It suggests that IL-24 and VEGF-C may be associated with the development and lymph node metastasis of CSC .