CAJ | 학술논문

目的通过检测白细胞介素-22（IL-22）在人早孕期母胎界面的表达，探讨其可能的作用。方法采用酶联免疫吸附法（enzyme-linked immuno sorbent assay, ELISA）检测正常早孕妇女及正常非孕育龄期妇女外周血、正常早孕妇女蜕膜组织及正常非孕育龄期妇女子宫内膜组织中IL-22的表达情况。结果早孕妇女外周血IL-22表达(105.33±6.61)pg/ml,显著高于正常非孕育龄期妇女外周血(84.71±6.73)pg/ml。与正常非孕育龄期妇女子宫内膜组织IL-22表达水平(86.02±7.79)pg/ml相比，早孕妇女蜕膜组织IL-22表达(109.98±6.87)pg/ml，显著增加。结论IL-22可能参与了正常妊娠母胎免疫耐受的建立和维持。
목적통과검측백세포개소-22（IL-22）재인조잉기모태계면적표체，탐토기가능적작용。방법채용매련면역흡부법（enzyme-linked immuno sorbent assay, ELISA）검측정상조잉부녀급정상비잉육령기부녀외주혈、정상조잉부녀세막조직급정상비잉육령기부녀자궁내막조직중IL-22적표체정황。결과조잉부녀외주혈IL-22표체(105.33±6.61)pg/ml,현저고우정상비잉육령기부녀외주혈(84.71±6.73)pg/ml。여정상비잉육령기부녀자궁내막조직IL-22표체수평(86.02±7.79)pg/ml상비，조잉부녀세막조직IL-22표체(109.98±6.87)pg/ml，현저증가。결론IL-22가능삼여료정상임신모태면역내수적건립화유지。
Objective To investigate the roles of the interleukin-22 (IL-22) in human Fetal-maternal Interface. Methods 15 women with normal early pregnancy were analyzed by enzyme-linked immuno sorbent assay (ELISA) for the levels of IL-22 in the peripheral blood and decidua, and l2 healthy non-pregnant fertile women as control in this study. Results The levels of IL-22 in the peripheral blood of the normal early pregnant women were significantly higher than that of the healthy non-pregnant fertile women (105.33±6.61pg/ml vs 84.71±6.73pg/ml)( <0.05).Compared with the levels of the IL-22 in the endometrium of healthy non-pregnant fertile women, that in the decidua of the normal early pregnancy increased significantly (109.98±6.87pg/ml vs 86.02±7.79pg/ml)( <0.05). Conclusion It is speculated that the elevated IL-22 may be involved in establishing and maintaining Fetal-maternal immune-tolerance.