CAJ | 학술논문

饮酒对中枢神经系统有重大影响，小胶质细胞是脑内原位免疫效应细胞，它在乙醇引起的神经毒性中有重要作用，可导致神经元死亡与退行性变；小胶质细胞有利于维持稳态而不是导致神经退行性变，小胶质细胞活化是乙醇引起损害的结果而不是损害的原因。本文对乙醇引起的神经元死亡和退行性变中小胶质细胞的反应及相应机制作一综述。
음주대중추신경계통유중대영향，소효질세포시뇌내원위면역효응세포，타재을순인기적신경독성중유중요작용，가도치신경원사망여퇴행성변；소효질세포유리우유지은태이불시도치신경퇴행성변，소효질세포활화시을순인기손해적결과이불시손해적원인。본문대을순인기적신경원사망화퇴행성변중소효질세포적반응급상응궤제작일종술。
Alcohol has a significant effect on the central nervous system, as the key immune effector cells in the brain, some studies proved that microglia plays an important role in the neurotoxicity of alcohol, which can lead to neuronal death and degeneration. Some investigations demonstrated that microglia is beneficial to maintain a steady state rather than causing nerve degeneration, microglia activation is the end of the damage induced by the alcohol rather than cause. This paper reviews the microglial response and related mechanism in neuronal death and degeneration caused by alcohol.