CAJ | 학술논문

色素上皮衍生因子是一种强有力的新生血管抑制因子,除具有神经营养、神经保护、调节血管通透性的作用,还具有改善胰岛素抵抗、抑制炎性反应、抗氧化应激、抑制血管平滑肌细胞增殖及迁移、抑制新生血管、抑制血栓形成和抑制C反应蛋白生成等效应,因此可以延缓2型糖尿病大血管并发症的发生、发展.
색소상피연생인자시일충강유력적신생혈관억제인자,제구유신경영양、신경보호、조절혈관통투성적작용,환구유개선이도소저항、억제염성반응、항양화응격、억제혈관평활기세포증식급천이、억제신생혈관、억제혈전형성화억제C반응단백생성등효응,인차가이연완2형당뇨병대혈관병발증적발생、발전.
Pigment epithelium-derived factor (PEDF),a potent inhibitor of neovascularization,exerts neurotrophic,neuroprotective,and vascular permeability-regulative effects.In addition,PEDF not only ameliorates insulin resistance,but also inhibits inflammation,attenuates oxidation,suppresses proliferation and migration of vascular smooth muscle cells,inhibits angiogenesis,blocks thrombus formation,hinder the C-reactive protein,and so on.Consequently,PEDF could defer the occurrence and progress of macrovascular complications in type 2 diabetes mellitus.