CAJ | 학술논문

骨髓间充质干细胞(BMSCs)是一种良好的种子细胞,广泛用于椎间盘组织工程研究.椎间盘退变机制、BMSCs的生物学特性、支架材料及细胞因子认识的深入,为BMSCs应用于退变的椎间盘组织的修复奠定了一定基础.但是组织工程学应用BMSCs治疗椎间盘退行性病变还处于研究的初期阶段,目前仍存在很多问题,其中最为突出的是移植细胞存活问题.笔者就BMSCs治疗椎间盘退行性病变的相关研究作一综述.
골수간충질간세포(BMSCs)시일충량호적충자세포,엄범용우추간반조직공정연구.추간반퇴변궤제、BMSCs적생물학특성、지가재료급세포인자인식적심입,위BMSCs응용우퇴변적추간반조직적수복전정료일정기출.단시조직공정학응용BMSCs치료추간반퇴행성병변환처우연구적초기계단,목전잉존재흔다문제,기중최위돌출적시이식세포존활문제.필자취BMSCs치료추간반퇴행성병변적상관연구작일종술.
Bone marrow mesenchymal stem cells (BMSCs) is a good seed cell,and it is widely used in intervertebral disc tissue engineering research.The improvement of cellular scaffolds,cell factors and further understanding of intervertebral disc (IVD) cell pathophysiology and BMSCs biology have laid the foundation for cell-based therapies for IVD degeneration.However,BMSCs repairing IVD is still in the early stage of research,at present there are still many problems,one of the most prominent is the survival of transplanted cells.This review mainly introduces the current research status of BMSCs in IVD tissue engineering.