CAJ | 학술논문

目的：研究高尿酸血症与青年脑梗死的关系。方法对2011-01-2013-01在我院住院的150例青年脑梗死（年龄＜45岁）患者进行血尿酸水平测定及颈动脉血管彩超检查（观察颈动脉有无斑块形成），并与对照组（同期在我院体检的健康者）进行比较。结果脑梗死组颈动脉斑块发生率及高尿酸血症检出率和血尿酸水平均高于对照组（P＜0.01），其中颈动脉有斑块组血尿酸水平和高尿酸血症的检出率明显高于无斑块组，两者相比差异有显著性（ P＜0.01）。结论早发性动脉粥样硬化是青年脑梗死的重要病因，高尿酸血症可预测颈动脉粥样硬化的发生，是青年脑梗死的重要危险因素。临床上对青年脑梗死患者，尤其是那些既往无传统脑血管病危因素者，应将血尿酸水平测定作为常规生化检测项目。
목적：연구고뇨산혈증여청년뇌경사적관계。방법대2011-01-2013-01재아원주원적150례청년뇌경사（년령＜45세）환자진행혈뇨산수평측정급경동맥혈관채초검사（관찰경동맥유무반괴형성），병여대조조（동기재아원체검적건강자）진행비교。결과뇌경사조경동맥반괴발생솔급고뇨산혈증검출솔화혈뇨산수평균고우대조조（P＜0.01），기중경동맥유반괴조혈뇨산수평화고뇨산혈증적검출솔명현고우무반괴조，량자상비차이유현저성（ P＜0.01）。결론조발성동맥죽양경화시청년뇌경사적중요병인，고뇨산혈증가예측경동맥죽양경화적발생，시청년뇌경사적중요위험인소。림상상대청년뇌경사환자，우기시나사기왕무전통뇌혈관병위인소자，응장혈뇨산수평측정작위상규생화검측항목。
Objective To study the relationship between hyperuricemia and cerebral infarction in young adults.Methods We measured the level of serum uric acid and did carotid vascular ultrasonography (observing if there was carotid plaques for-mation)in 150 young patients with cerebral infarction in our hospital (less than 45 years of age) from January 2011 to 2013 ,and compared with the control group (the healthy people doing physical examination in our hospital at the same period ).Results The incidence of the plaque of carotid artery and hyperuricemia as well as the levels of uric acid in cerebral infarction group were higher than those in the control group (P<0.01). The levels of serum uric acid and the incidence of hyperuricemia in the group of carotid artery plague were significantly higher than those of the group without plaque ,with significant difference (P<0.01) .Conclusion Early atherosclerosis is an important cause of cerebral infarction in young adults.Hyperuricemia is predic-tive of carotid atherosclerosis ,and is an important risk factor for cerebral infarction in young adults. Clinically for cerebral in-farction in young patients ,especially those with no previous history of traditional cerebrovascular risk factors ,the levels of ser-um uric acid should be measured as routine biochemistry test.