中国中西医结合外科杂志
中國中西醫結閤外科雜誌
중국중서의결합외과잡지
CHINESE JOURNAL OF SURGERY OF INTEGRATED TRADITIONAL AND WESTERN MEDICINE
2013年
6期
664-666
,共3页
李晓明%郭东辉%石国君%李瑞亮%张洪相%苏长生%沈润斌%王红玉%李运美%袁福禄%韩广普
李曉明%郭東輝%石國君%李瑞亮%張洪相%囌長生%瀋潤斌%王紅玉%李運美%袁福祿%韓廣普
리효명%곽동휘%석국군%리서량%장홍상%소장생%침윤빈%왕홍옥%리운미%원복록%한엄보
股骨头坏死%丹参酮%髓芯减压%植骨%犬
股骨頭壞死%丹參酮%髓芯減壓%植骨%犬
고골두배사%단삼동%수심감압%식골%견
Osteonecrosis%tanshinone%core decompression%graft%dog
目的：研究丹参酮Ⅱ-a磺酸钠结合打压植骨治疗犬股骨头坏死的疗效。方法：以液氮冷冻法制作犬单侧股骨头缺血性坏死模型，随机分为两组，实验组采用将浸泡过丹参酮Ⅱ-a磺酸钠的松质骨植入到股骨头内，对照组将松质骨植入股骨头内，术后进行X线摄片、标本组织学及扫描电镜检查。结果：实验组股骨头骨密度较术前增高，透光区较小，组织学显示实验组骨空陷窝数和脂肪细胞直径较对照组明显改善（P＜0.05）。术后12周，扫描电镜可见再生软骨表面与正常透明软骨极为相似，成骨细胞增殖活跃，骨细胞成圆形，核膜清晰，趋于成熟。结论：丹参酮Ⅱ-a磺酸钠能改善股骨头血供，促进坏死骨的吸收、修复与重建。
目的：研究丹參酮Ⅱ-a磺痠鈉結閤打壓植骨治療犬股骨頭壞死的療效。方法：以液氮冷凍法製作犬單側股骨頭缺血性壞死模型，隨機分為兩組，實驗組採用將浸泡過丹參酮Ⅱ-a磺痠鈉的鬆質骨植入到股骨頭內，對照組將鬆質骨植入股骨頭內，術後進行X線攝片、標本組織學及掃描電鏡檢查。結果：實驗組股骨頭骨密度較術前增高，透光區較小，組織學顯示實驗組骨空陷窩數和脂肪細胞直徑較對照組明顯改善（P＜0.05）。術後12週，掃描電鏡可見再生軟骨錶麵與正常透明軟骨極為相似，成骨細胞增殖活躍，骨細胞成圓形，覈膜清晰，趨于成熟。結論：丹參酮Ⅱ-a磺痠鈉能改善股骨頭血供，促進壞死骨的吸收、脩複與重建。
목적：연구단삼동Ⅱ-a광산납결합타압식골치료견고골두배사적료효。방법：이액담냉동법제작견단측고골두결혈성배사모형，수궤분위량조，실험조채용장침포과단삼동Ⅱ-a광산납적송질골식입도고골두내，대조조장송질골식입고골두내，술후진행X선섭편、표본조직학급소묘전경검사。결과：실험조고골두골밀도교술전증고，투광구교소，조직학현시실험조골공함와수화지방세포직경교대조조명현개선（P＜0.05）。술후12주，소묘전경가견재생연골표면여정상투명연골겁위상사，성골세포증식활약，골세포성원형，핵막청석，추우성숙。결론：단삼동Ⅱ-a광산납능개선고골두혈공，촉진배사골적흡수、수복여중건。
Objective: To analyze the efficiency of bone impaction grafting with Tanshinone Ⅱ-a in the treatment of Canine osteonecrosis of the femoral head. Methods Twelve canine models were made with femo-ral head avascular necrosis induced by liquid nitrogen frozen, and were randomly divided into two groups. In the experimental group cancellous bone soaked in Tanshi-none Ⅱ-a was implanted into the femoral head, and in the control group cancellous bone was implanted only. X-ray, specimen histology and scanning elec-tron microscopy were done postoperatively Results In the experimental group, the (bone mass density BMD) of the femoral head was higher. Light transmission area was smaller than the control group; bone histology showed in the experimental group, the number of empty lacunae and fat cell diameter was significantly improved as com-pared with the control group (P<0.05). After twelve weeks, scanning electron microscopy showed that cartilage surface was very similar to normal hyaline cartilage and active proli-feration of osteoblasts, mature osteocytes were shown into a round, clear membrane. Conclusion Tanshinone Ⅱ-a can improve the blood supply of the femoral head and promote the absorption of necrotic bone repair and reconstruction.
