CAJ | 학술논문

目的：探讨HLA-DRB1等位基因多态性与广西汉族婴幼儿皮肤血管瘤的遗传相关性。方法：将广西汉族88例婴幼儿皮肤血管瘤患者（病例组）和105例正常汉族婴幼儿（对照组）作为研究对象。采用聚合酶链反应-序列特异性引物分型技术对两组HLA-DRB1等位基因进行分型，SPSS软件进行统计分析。结果：病例组HLA-DRB1*16等位基因频率为28.98％，明显高于对照组的14.76％（ RR＝3.29，P＜0.05）；病例组HLA-DRB1*1401等位基因频率为6.82％，明显低于对照组的16.67％（ RR＝0.32，P＜0.05）。结论：HLA-DRB1*16可能为广西汉族婴幼儿皮肤血管瘤的易感基因。而 HLA-DRB1*1401可能为其保护基因。
목적：탐토HLA-DRB1등위기인다태성여엄서한족영유인피부혈관류적유전상관성。방법：장엄서한족88례영유인피부혈관류환자（병례조）화105례정상한족영유인（대조조）작위연구대상。채용취합매련반응-서렬특이성인물분형기술대량조HLA-DRB1등위기인진행분형，SPSS연건진행통계분석。결과：병례조HLA-DRB1*16등위기인빈솔위28.98％，명현고우대조조적14.76％（ RR＝3.29，P＜0.05）；병례조HLA-DRB1*1401등위기인빈솔위6.82％，명현저우대조조적16.67％（ RR＝0.32，P＜0.05）。결론：HLA-DRB1*16가능위엄서한족영유인피부혈관류적역감기인。이 HLA-DRB1*1401가능위기보호기인。
Objective:To explore the genetic correlation between HLA-DRB1 allele polymor-phisms and infantile cutaneous hemangioma in Guangxi Han population .Methods:88 patients with infantile cutaneous hemangioma ( study group ) and 105 normal individuals ( control group ) were selected in Guangxi Han population as study subjects .HLA-DRB1 alleles in two groups were typed by polymerase chain reaction -sequence specific primers ( PCR -SSP ) .SPSS software was used for statistical analysis .Results:The frequency of HLA-DRB1*16 allele in the study group was significantly higher than that in the control group ( 28.98% vs 14.76%, RR =3.29 , P <0.05 ) .Whereas the frequency of HLA-DRB1*1401 allele in study group was significantly lower than that in control group (6.82% vs 16.67%,RR=0.32,P<0.05).Conclusion:In Guangxi Han population , HLA-DRB1*16 may be the predisposing gene of infantile cutaneous hemangio-ma, whileas HLA-DRB1*1401 may be the protective gene .