中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2013年
6期
917-919
,共3页
原癌基因人类表皮生长因子受体2%增殖细胞核抗原%子宫内膜非典型增生%子宫内膜癌
原癌基因人類錶皮生長因子受體2%增殖細胞覈抗原%子宮內膜非典型增生%子宮內膜癌
원암기인인류표피생장인자수체2%증식세포핵항원%자궁내막비전형증생%자궁내막암
cerbB-2%PCNA%atypical hyperplasia of endometrium%endometrial carcinoma
目的：探讨原癌基因人类表皮生长因子受体2（cerbB-2）、增殖细胞核抗原（PCNA）在子宫内膜病变中的表达及其临床意义。方法应用免疫组织化学SP法检测cerbB-2、PCNA在20例正常子宫内膜、20例子宫内膜非典型增生及66例子宫内膜癌中的表达，分析其表达及与临床分期、组织学分级、肿瘤肌层浸润相关性。结果 cerbB-2、PCNA表达阳性率在正常子宫内膜、子宫内膜非典型增生与到子宫内膜癌的表达逐渐升高，正常子宫内膜和子宫内膜非典型增生分别与子宫内膜癌表达阳性率比较，差异均有统计学意义（χ2值分别为39．29、30．66、15．93、5．98，均P＜0．05）；随临床分期、肌层浸润、组织学分级的增高而升高，差异均有统计学意义（均P＜0．05）。结论 cerbB-2、PCNA与子宫内膜癌的发生、发展及预后相关。
目的：探討原癌基因人類錶皮生長因子受體2（cerbB-2）、增殖細胞覈抗原（PCNA）在子宮內膜病變中的錶達及其臨床意義。方法應用免疫組織化學SP法檢測cerbB-2、PCNA在20例正常子宮內膜、20例子宮內膜非典型增生及66例子宮內膜癌中的錶達，分析其錶達及與臨床分期、組織學分級、腫瘤肌層浸潤相關性。結果 cerbB-2、PCNA錶達暘性率在正常子宮內膜、子宮內膜非典型增生與到子宮內膜癌的錶達逐漸升高，正常子宮內膜和子宮內膜非典型增生分彆與子宮內膜癌錶達暘性率比較，差異均有統計學意義（χ2值分彆為39．29、30．66、15．93、5．98，均P＜0．05）；隨臨床分期、肌層浸潤、組織學分級的增高而升高，差異均有統計學意義（均P＜0．05）。結論 cerbB-2、PCNA與子宮內膜癌的髮生、髮展及預後相關。
목적：탐토원암기인인류표피생장인자수체2（cerbB-2）、증식세포핵항원（PCNA）재자궁내막병변중적표체급기림상의의。방법응용면역조직화학SP법검측cerbB-2、PCNA재20례정상자궁내막、20례자궁내막비전형증생급66례자궁내막암중적표체，분석기표체급여림상분기、조직학분급、종류기층침윤상관성。결과 cerbB-2、PCNA표체양성솔재정상자궁내막、자궁내막비전형증생여도자궁내막암적표체축점승고，정상자궁내막화자궁내막비전형증생분별여자궁내막암표체양성솔비교，차이균유통계학의의（χ2치분별위39．29、30．66、15．93、5．98，균P＜0．05）；수림상분기、기층침윤、조직학분급적증고이승고，차이균유통계학의의（균P＜0．05）。결론 cerbB-2、PCNA여자궁내막암적발생、발전급예후상관。
Objective To investigate the expression and clinical significance of cerbB-2 and PCNA in endometrial carcinoma .Methods Immunohistochemical assay was used to detect the expression of cerbB-2 and PCNA in sections of 20 cases of normal endometrium , 20 cases of atypical hyperplasia , and 66 cases of endometrial carcinoma .The correlation between their expression and clinical staging , histological grade , and myometrial invasion was analyzed .Results The positive rate of cerbB-2 and PCNA expression increased gradually in normal endometrial tissue , atypical hyperplasia and endometrial carcinoma .Their positive rate in endometrial carcinoma was statistically different from that in normal endometrium and atypical hyperplasia (χ2 value was 39.29, 30.66, 15.93 and 5.98, respectively, all P<0.05).With the increasing of histological grades , the depth of myometrial invasion, and clinical stage, the expression of cerbB-2 and PCNA increased, and there were significant difference (all P<0.05).Conclusion The expression of cerbB-2 and PCNA is correlated with the occurrence , development and prognosis of endometrial carcinoma .
