中国妇幼健康研究
中國婦幼健康研究
중국부유건강연구
CHINESE JOURNAL OF MATERNAL AND CHILD HEALTH RESEARCH
2013年
6期
915-917
,共3页
盆腔淋巴结%高危型人乳头状瘤病毒%宫颈癌%微转移
盆腔淋巴結%高危型人乳頭狀瘤病毒%宮頸癌%微轉移
분강림파결%고위형인유두상류병독%궁경암%미전이
pelvic lymph node%high-risk type human papilloma virus%cervical carcinoma%micro transfer
目的:探讨宫颈癌患者盆腔淋巴结高危型人乳头状瘤病毒16/18( HPVl6/18) DNA检出情况与宫颈癌临床病理特征的相关性,同时探讨宫颈癌原发灶和盆腔淋巴结组织中HPVDNA检出的相关性及意义。方法采用前瞻性研究方法,收集鄂州市中心医院自2011年1月至2012年6月间收治的行宫颈癌根治术患者的石蜡标本,采用聚合酶链反应( PCR)方法,检测33例宫颈癌组织及115枚盆腔淋巴结组织中HPVl6/18 DNA。结果33例宫颈癌患者中盆腔淋巴结HPV16/18阳性检出率为54.55%(18/33),其阳性检出率与临床分期、有无淋巴结转移、病理分化程度、肌层浸润深度、有无宫体及阴道侵犯有关,差异均有统计学意义(χ2值分别为9.528、5.241、10.481、7.187、3.915、7.274,均P<0.05)。宫颈癌组织HPV16/18阳性检出率为72.73%(24/33),与盆腔淋巴结HPV16/18阳性检出率进行相关分析,二者呈正相关(r=0.398,P<0.05)。淋巴结转移组与淋巴结未转移组总淋巴结个数的HPV16/18阳性检出率进行比较,差异有统计学意义(χ2=36.449,P<0.05)。结论检测盆腔淋巴结有助于发现早期隐匿性转移,HPV可以作为检测微转移的特异性标志物。
目的:探討宮頸癌患者盆腔淋巴結高危型人乳頭狀瘤病毒16/18( HPVl6/18) DNA檢齣情況與宮頸癌臨床病理特徵的相關性,同時探討宮頸癌原髮竈和盆腔淋巴結組織中HPVDNA檢齣的相關性及意義。方法採用前瞻性研究方法,收集鄂州市中心醫院自2011年1月至2012年6月間收治的行宮頸癌根治術患者的石蠟標本,採用聚閤酶鏈反應( PCR)方法,檢測33例宮頸癌組織及115枚盆腔淋巴結組織中HPVl6/18 DNA。結果33例宮頸癌患者中盆腔淋巴結HPV16/18暘性檢齣率為54.55%(18/33),其暘性檢齣率與臨床分期、有無淋巴結轉移、病理分化程度、肌層浸潤深度、有無宮體及陰道侵犯有關,差異均有統計學意義(χ2值分彆為9.528、5.241、10.481、7.187、3.915、7.274,均P<0.05)。宮頸癌組織HPV16/18暘性檢齣率為72.73%(24/33),與盆腔淋巴結HPV16/18暘性檢齣率進行相關分析,二者呈正相關(r=0.398,P<0.05)。淋巴結轉移組與淋巴結未轉移組總淋巴結箇數的HPV16/18暘性檢齣率進行比較,差異有統計學意義(χ2=36.449,P<0.05)。結論檢測盆腔淋巴結有助于髮現早期隱匿性轉移,HPV可以作為檢測微轉移的特異性標誌物。
목적:탐토궁경암환자분강림파결고위형인유두상류병독16/18( HPVl6/18) DNA검출정황여궁경암림상병리특정적상관성,동시탐토궁경암원발조화분강림파결조직중HPVDNA검출적상관성급의의。방법채용전첨성연구방법,수집악주시중심의원자2011년1월지2012년6월간수치적행궁경암근치술환자적석사표본,채용취합매련반응( PCR)방법,검측33례궁경암조직급115매분강림파결조직중HPVl6/18 DNA。결과33례궁경암환자중분강림파결HPV16/18양성검출솔위54.55%(18/33),기양성검출솔여림상분기、유무림파결전이、병리분화정도、기층침윤심도、유무궁체급음도침범유관,차이균유통계학의의(χ2치분별위9.528、5.241、10.481、7.187、3.915、7.274,균P<0.05)。궁경암조직HPV16/18양성검출솔위72.73%(24/33),여분강림파결HPV16/18양성검출솔진행상관분석,이자정정상관(r=0.398,P<0.05)。림파결전이조여림파결미전이조총림파결개수적HPV16/18양성검출솔진행비교,차이유통계학의의(χ2=36.449,P<0.05)。결론검측분강림파결유조우발현조기은닉성전이,HPV가이작위검측미전이적특이성표지물。
Objective To explore the correlation between detection of high-risk type human papilloma virus 16/18(HPVl6/18) DNA in pelvic lymph node in patients with cervical carcinoma and clinicopathologic features , and to investigate the correlation and clinical significance of primary cervical cancer focus and HPVDNA in pelvic lymph node .Methods With prospective study method , patients undergoing radical hysterectomy of cervical carcinoma in Ezhou Center Hospital from January 2011 to June 2012 were recruited .Polymerase chain reaction ( PCR) was adopted to test cervical cancer tissues of 33 cases and HPVl6/18 DNA in 115 pieces of pelvic lymph node . Results The positive detection rate of pelvic lymph node HPV16/18 in 33 cases was 54.55%(18/33), and it was correlated with clinical stage, lymph node metastasis , pathology differentiation degree , muscle layer infiltration depth , corpus and vaginal infiltration .The differences had statistical significance (χ2 value was 9.528, 5.241, 10.481, 7.187, 3.915 and 7.274, respectively, all P<0.05).The positive detection rate of HPV16/18 in cervical carcinoma tissue was 72.73%(24/33), and it was positively correlated with that of pelvic lymph node HPV16/18 (r=0.398, P<0.05).The positive detection rate of HPV16/18 of the total number in lymph node metastasis group and the group without lymph node metastasis was statistically different (χ2 =36.449, P<0.05).Conclusion Detecting pelvic lymph node is helpful to detect early occult metastases , and HPV can be used as specific marker of micro transfer .