CAJ | 학술논문

目的：本研究旨在探讨年龄对原发性肝癌肝切除患者的临床病理特征及预后的影响。方法：回顾性分析172例行肝切除术的原发性肝癌患者，对年龄与患者临床病理及预后因素之间的关系进行探讨。结果：原发性肝癌患者低龄组（≤53岁）的肝脏储备情况较高龄组患者（﹥53岁）好，但是低龄组也存在更多的肿瘤侵袭因素。在经过117个月追踪随访之后，87人确认死亡。低龄组患者的5年累积生存率为55.43%，而高龄组患者的5年累积生存率为48.31%（P ＝0.026）。多因素分析结果显示，年龄是影响原发性肝癌肝切除患者术后生存情况的危险因素。此外，172例随访病人中有76例在术后出现了肿瘤复发。多因素分析发现对于低龄组患者和高龄组患者，肝切除术后肿瘤的复发无统计学差异。结论：年龄是影响原发性肝癌肝切除术后患者生存情况的危险因素，但是与患者术后肿瘤复发未见明显关系。
목적：본연구지재탐토년령대원발성간암간절제환자적림상병리특정급예후적영향。방법：회고성분석172례행간절제술적원발성간암환자，대년령여환자림상병리급예후인소지간적관계진행탐토。결과：원발성간암환자저령조（≤53세）적간장저비정황교고령조환자（﹥53세）호，단시저령조야존재경다적종류침습인소。재경과117개월추종수방지후，87인학인사망。저령조환자적5년루적생존솔위55.43%，이고령조환자적5년루적생존솔위48.31%（P ＝0.026）。다인소분석결과현시，년령시영향원발성간암간절제환자술후생존정황적위험인소。차외，172례수방병인중유76례재술후출현료종류복발。다인소분석발현대우저령조환자화고령조환자，간절제술후종류적복발무통계학차이。결론：년령시영향원발성간암간절제술후환자생존정황적위험인소，단시여환자술후종류복발미견명현관계。
Objective:Age Plays an imPortant role on the Prognosis of Patients with eCC after resection surgery. Whether older Patients should receive resection surgery remains controversial. We aim to comPare the clinicoPathologi-cal features and Prognoses between younger and older Patients with eCC undergoing resection. Methods:The clinical records of 172 Patients with hePatocellular carcinoma undergoing resection surgery were analyzed retrosPectively,and the follow - uP of these Patients was Performed. We investigated the correlation between the factor of age and the clini-coPathological features or Prognoses. Results:The younger Patients(≤53)had better liver functional reserve but more aggressive tumor factors than the older Patients( ﹥ 53). After a median follow - uP of 31 months,87 Patients died. The cumulative 5 - year survival rates were 55. 43% in younger Patients and 48. 31% in the older Patients(P = 0. 026). Using multivariate analysis,we demonstrated that age was an indePendent risk factor associated with overall survival. Besides,there were 76 Patients who had tumor recurrence after surgery. Using multivariate analysis,we failed to find that the incidence of tumor recurrence in younger Patients was comParable to that in the older Patients. Conclusion:Age is a risk factor to determine the survival of Patients with eCC who underwent resection. eowever,no correlation was observed between recurrence and age.