CAJ | 학술논문

血管新生与神经发育存在相同的分子信号机制。神经元轴突导向分子Slit-Robo在神经发育中调节神经元前体细胞定向迁移和神经元轴突定向生长的作用已经明确。近年来Slit-Robo在血管新生方面的研究受到关注。本文就Slit-Robo信号通路对眼部新生血管的作用做一综述以推进其在眼科领域的研究。
혈관신생여신경발육존재상동적분자신호궤제。신경원축돌도향분자Slit-Robo재신경발육중조절신경원전체세포정향천이화신경원축돌정향생장적작용이경명학。근년래Slit-Robo재혈관신생방면적연구수도관주。본문취Slit-Robo신호통로대안부신생혈관적작용주일종술이추진기재안과영역적연구。
The migration and patterning of axons and blood vessels share similar guidance mechanisms.Slits and their Roundabout ( Robo) receptors were initially characterized as repulsive guidance cues for neuronal axons and mediate the migration of neuronal precursor cells during neural development .In recent years , the research of Slit/Robo signal pathway on neovascularization has become one of hot topics.This review will focus on the role of Slit/Robo signal pathway in ocular neovascularization to promote the research of Slit/Robo signaling on ophthalmology.