CAJ | 학술논문

【目的】探讨氨磺必利治疗精神分裂症的临床疗效与安全性。【方法】121例精神分裂症患者随机分为氨磺必利组（N＝61）与奥氮平组（N＝60）两组，分别予以氨磺必利与奥氮平治疗，疗程12周。采用阳性和阴性症状量表（PANSS）、副反应量表（TESS）评定疗效和不良反应。【结果】治疗12周后，氨磺必利组的有效率为83．6％，奥氮平组的有效率为86．7％，两组的差异无统计学意义（ P ＞0．05）；氨磺必利组与奥氮平组患者PANSS总分治疗后（41．79±9．66，46．56±9．88）均较治疗前（91．76±13．06，94．83±15．67）有显著下降（ P ＜0．01）；氨磺必利组患者在治疗12周后 PANSS阴性症状分值为（9．61±3．86）分，降低较奥氮平组（12．56±6．15）更为显著（ P ＜0．05）。两组不良反应发生率的差异无统计学意义（ P ＞0．05）。【结论】氨磺必利与奥氮平总体疗效相似，对阴性症状改善较好，不良反应轻，安全性高。
【목적】탐토안광필리치료정신분렬증적림상료효여안전성。【방법】121례정신분렬증환자수궤분위안광필리조（N＝61）여오담평조（N＝60）량조，분별여이안광필리여오담평치료，료정12주。채용양성화음성증상량표（PANSS）、부반응량표（TESS）평정료효화불량반응。【결과】치료12주후，안광필리조적유효솔위83．6％，오담평조적유효솔위86．7％，량조적차이무통계학의의（ P ＞0．05）；안광필리조여오담평조환자PANSS총분치료후（41．79±9．66，46．56±9．88）균교치료전（91．76±13．06，94．83±15．67）유현저하강（ P ＜0．01）；안광필리조환자재치료12주후 PANSS음성증상분치위（9．61±3．86）분，강저교오담평조（12．56±6．15）경위현저（ P ＜0．05）。량조불량반응발생솔적차이무통계학의의（ P ＞0．05）。【결론】안광필리여오담평총체료효상사，대음성증상개선교호，불량반응경，안전성고。
[Objective]To explore clinical efficacy and safety of amisulpride in the treatment of schizophre-nia .[Methods] Totally 121 patients with schizophrenia were randomly assigned to amisulpride group ( n=61) and olanzapine group( n=60) .Two groups were treated with amisulpride and olanzapine respectively for 12 weeks .The efficacy and side reactions were evaluated with positive and negative syndrome scale (PANSS) and treatment emergent symptom scale (TESS ) .[Results] After 12 weeks of treatment , the effective rate of amisulpride and olanzapine were 83 .6% and 86 .7% respectively ,but there was no significant difference be-tween two groups( P > 0 .05) .Compared with before treatment ,the total scores of PANSS in amisulpride group and olanzapine group after treatment were significantly decreased [(41 .79 ± 9 .66) vs .(91 .76 ± 13 .06) , (46 .56 ± 9 .88) vs .(94 .83 ± 15 .67)]( P <0 .01) .The negative symptom scores of PANSS in amisulpride group after 12 weeks of treatment were decreased more significant than those in olanzapine group [(9 .61 ± 3 .86) vs .(12 .56 ± 6 .15)]( P <0 .05) .There was no significant difference in the incidence of side reaction between two groups ( P > 0 .05) .[Conclusion]The total efficacy of amisulpride is similar to olanzapine ,. Amisulpride can better improve negative symptoms ,and has mild side reaction and high safety .