中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
21期
9656-9658
,共3页
马天%姜文成%陈洁%李斌
馬天%薑文成%陳潔%李斌
마천%강문성%진길%리빈
银屑病%白细胞介素23%CD4阳性T淋巴细胞
銀屑病%白細胞介素23%CD4暘性T淋巴細胞
은설병%백세포개소23%CD4양성T림파세포
Psoriasis%Interleukin-23%CD4-positive T-lymphocytes
银屑病(psoriasis)是多种免疫细胞共同参与的慢性复发性炎症性皮肤病,它具有明显的鳞屑性红斑和不同程度的自觉症状,严重影响患者的生活质量。该病的发病机制探讨多集中在遗传、感染、免疫等方面。目前,越来越多的研究证明了IL-23和CD4阳性辅助性T淋巴细胞17(CD4+T helper 17, Th17)在银屑病病理机制中起到了关键作用。本文就银屑病发病机制的进展作一综述。
銀屑病(psoriasis)是多種免疫細胞共同參與的慢性複髮性炎癥性皮膚病,它具有明顯的鱗屑性紅斑和不同程度的自覺癥狀,嚴重影響患者的生活質量。該病的髮病機製探討多集中在遺傳、感染、免疫等方麵。目前,越來越多的研究證明瞭IL-23和CD4暘性輔助性T淋巴細胞17(CD4+T helper 17, Th17)在銀屑病病理機製中起到瞭關鍵作用。本文就銀屑病髮病機製的進展作一綜述。
은설병(psoriasis)시다충면역세포공동삼여적만성복발성염증성피부병,타구유명현적린설성홍반화불동정도적자각증상,엄중영향환자적생활질량。해병적발병궤제탐토다집중재유전、감염、면역등방면。목전,월래월다적연구증명료IL-23화CD4양성보조성T림파세포17(CD4+T helper 17, Th17)재은설병병리궤제중기도료관건작용。본문취은설병발병궤제적진전작일종술。
Psoriasis is one of the most common immune-mediated chronic inflammatory skin disorders associated with the typical erythematous, scaly skin lesions, which can significantly impact quality of life. The pathogenesis of the disease are mainly about genetics, infection and immunity. Recently, more and more research demonstrated that Interleukin-23 (IL-23) and CD4+ T helper 17 (Th17) cells were thought to be critical in psoriasis pathogenesis. This review updates the pathogenesis of Psoriasis.