中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
21期
9534-9537
,共4页
王芝涛%李延莉%陶千山%秦慧%翟志敏
王芝濤%李延莉%陶韆山%秦慧%翟誌敏
왕지도%리연리%도천산%진혜%적지민
多发性骨髓瘤%白蛋白类%校正后血清钙
多髮性骨髓瘤%白蛋白類%校正後血清鈣
다발성골수류%백단백류%교정후혈청개
Multiple myeloma%Albumin%Corrected serum calcium
目的：分析经白蛋白校正后血钙在多发性骨髓瘤患者中的应用及临床意义。方法选自我院收治初诊多发性骨髓瘤患者71例，测定其血钙浓度值、血清白蛋白值等。校正公式：校正血钙值（mmol/L）＝血清总钙测定值（mmol/L）＋（40-血清白蛋白测定值）×0.025（mmol/L）。以血肌酐＜176.8μmol/L为A组；血肌酐＞176.8μmol/L为B组。结果71例多发性骨髓瘤患者血钙浓度为（2.31±0.45）mmol/L，校正后血钙浓度为（2.61±0.48）mmol/L，校正前后血钙浓度差异具有统计学意义（P＜0.001）。高钙血症患者构成比由14.1%升至校正后的21.1%，低钙血症构成比由53.5%下降至校正后的15.5%，正常血钙组患者例数增加。A、B组患者之间血钙浓度校正前后均无统计学差异（P＞0.05）。71例患者中位随访时间25个月。血钙浓度与溶骨部位多少及生存时间均无明显相关性。结论校正血钙值更好地反映疾病严重程度；高钙血症与肾功能不全存在相关性。
目的：分析經白蛋白校正後血鈣在多髮性骨髓瘤患者中的應用及臨床意義。方法選自我院收治初診多髮性骨髓瘤患者71例，測定其血鈣濃度值、血清白蛋白值等。校正公式：校正血鈣值（mmol/L）＝血清總鈣測定值（mmol/L）＋（40-血清白蛋白測定值）×0.025（mmol/L）。以血肌酐＜176.8μmol/L為A組；血肌酐＞176.8μmol/L為B組。結果71例多髮性骨髓瘤患者血鈣濃度為（2.31±0.45）mmol/L，校正後血鈣濃度為（2.61±0.48）mmol/L，校正前後血鈣濃度差異具有統計學意義（P＜0.001）。高鈣血癥患者構成比由14.1%升至校正後的21.1%，低鈣血癥構成比由53.5%下降至校正後的15.5%，正常血鈣組患者例數增加。A、B組患者之間血鈣濃度校正前後均無統計學差異（P＞0.05）。71例患者中位隨訪時間25箇月。血鈣濃度與溶骨部位多少及生存時間均無明顯相關性。結論校正血鈣值更好地反映疾病嚴重程度；高鈣血癥與腎功能不全存在相關性。
목적：분석경백단백교정후혈개재다발성골수류환자중적응용급림상의의。방법선자아원수치초진다발성골수류환자71례，측정기혈개농도치、혈청백단백치등。교정공식：교정혈개치（mmol/L）＝혈청총개측정치（mmol/L）＋（40-혈청백단백측정치）×0.025（mmol/L）。이혈기항＜176.8μmol/L위A조；혈기항＞176.8μmol/L위B조。결과71례다발성골수류환자혈개농도위（2.31±0.45）mmol/L，교정후혈개농도위（2.61±0.48）mmol/L，교정전후혈개농도차이구유통계학의의（P＜0.001）。고개혈증환자구성비유14.1%승지교정후적21.1%，저개혈증구성비유53.5%하강지교정후적15.5%，정상혈개조환자례수증가。A、B조환자지간혈개농도교정전후균무통계학차이（P＞0.05）。71례환자중위수방시간25개월。혈개농도여용골부위다소급생존시간균무명현상관성。결론교정혈개치경호지반영질병엄중정도；고개혈증여신공능불전존재상관성。
ObjectiveTo analyse the significance of serum calcium after correction by albumin in multiple myeloma patients, and compare the correlation between different stages, groups and bone destruction with the corrected calcium.MethodsWe evaluated serum calcium, albumin in 71 multiple myeloma patients. The serum calcium levels were corrected according to the following formual: corrected serum calcium=total calcium(mmol/L)+[40-serum albumin concentration (g/L)]×0.025 mmol/L.ResultsThere was a significant difference between the mean serum calcium before and after correction in multiple myeloma patients [(2.30±0.49)mmol/Lvs. (2.54±0.52)mmol/L,P<0.001]. The constituent ratio of patients with hypercalcemia reached from 14.1% to 21.1% after correction, patients with hypocalcemia ratio decreased from 53.5% to 15.5% after correction and the number of normal calcium group increased. No statistical significance existed between group A and B(P>0.05).71 cases of patients with a median survival time of 25 months. There was no obvious correlation between dissolved bone parts and live time with serum calcium.ConclusionTheserum calcium after correction by albumin may exactly reflect the severity of the disease. Obvious correlation existed between hypercalcemia and renal insufficiency.
