CAJ | 학술논문

目的：比较婴幼儿呼吸道合胞病毒（RSV）和人鼻病毒（HRV）急性下呼吸道感染的临床特征，探讨婴幼儿期RSV急性下呼吸道感染患儿后期哮喘和反复喘息的发生与HRV感染患儿是否存在差异。方法采用 RT-PCR 或 PCR 方法检测住院患儿咽拭子或鼻咽吸取物中常见的呼吸道感染病毒，选取单一RSV和HRV感染病例，回顾性比较两组患者的临床特征并进行随访。结果 RSV感染组纳入病例80例， HRV感染组纳入32例。两组患儿的临床特征相似，但RSV感染组患儿年龄偏小（P＝0.004），有喘息表现者明显多于 HRV 感染组（P＝0.000）。在与哮喘和反复喘息发生的关系上，两组间的差异无统计学意义（P值均为1.000）。结论婴幼儿RSV和HRV急性下呼吸道感染的临床特征相似，但在平均年龄、临床喘息的发生率等方面存在统计学差异。未发现婴幼儿期 RSV 感染患儿后期哮喘和反复喘息的发生与HRV感染患儿间存在差异。
목적：비교영유인호흡도합포병독（RSV）화인비병독（HRV）급성하호흡도감염적림상특정，탐토영유인기RSV급성하호흡도감염환인후기효천화반복천식적발생여HRV감염환인시부존재차이。방법채용 RT-PCR 혹 PCR 방법검측주원환인인식자혹비인흡취물중상견적호흡도감염병독，선취단일RSV화HRV감염병례，회고성비교량조환자적림상특정병진행수방。결과 RSV감염조납입병례80례， HRV감염조납입32례。량조환인적림상특정상사，단RSV감염조환인년령편소（P＝0.004），유천식표현자명현다우 HRV 감염조（P＝0.000）。재여효천화반복천식발생적관계상，량조간적차이무통계학의의（P치균위1.000）。결론영유인RSV화HRV급성하호흡도감염적림상특정상사，단재평균년령、림상천식적발생솔등방면존재통계학차이。미발현영유인기 RSV 감염환인후기효천화반복천식적발생여HRV감염환인간존재차이。
Objective To compare the clinical features of acute lower respiratory tract infection (ALRTI) with single RSV and HRV infection in infant, and to explore the differences of relationship between asthma and recurrent wheezing and the RSV or HRV infection.Methods Hospitalized patients with ALRTI from March 2007 to May 2010 were involved in this study. RT-PCR or PCR methods were applied to detect common respiratory tract viruses including respiratory syncytial virus (RSV), human rhinovirus (HRV), influenza virus (IFV), parainfluenza virus (PIV) type 1-4, adenovirus (ADV), enterovirus (EV), human coronavirus (HCOV), human meta pneumonia virus (HMPV) and human bocavirus (HBOV). Clinical feature of patients with single RSV and HRV infection were compared. Follow-up was carried out to investigate the incidence of recurrent wheezing or asthma after RSV and HRV infection. Results Eighty patients with single RSV infection and 32 patients with single HRV infection were enrolled into this study. All the patients with a normal white blood cell and C reactive protein. The mean age was (4.7±5.0) months in patients with RSV infection, and (9.8±8.8) months in patients with HRV infecton. A significant difference of the mean age between RSV group and HRV group (P=0.004) was found. The clinical features of ALRTI with RSV infection were similar with that of ALRTI with HRV infection in infant. However, the incidence of wheezing was lower in HRV infection patients (P=0.000). According to the follow-up study, no significant differences in the incidence of recurrent wheezing and asthma between the two group patients were found (P=1.000).ConclusionsThe clinical features of ALRTI with RSV infection are similar with HRV infection in infant, except in mean age, incidence of wheezing. There are no significant differences in the incidence of recurrent wheezing and asthma between the two group patients.