中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
21期
9753-9755
,共3页
组胺%受体,组胺%炎症%超敏反应%自身免疫
組胺%受體,組胺%炎癥%超敏反應%自身免疫
조알%수체,조알%염증%초민반응%자신면역
Histamine%Receptors,histamine%Inflammation%Hypersensitivity%Autoimmunity
在医学和生物学意义上，组胺是一种重要的生物胺类物质，但它在变态反应性疾病和自身免疫性疾病中的作用仍然知之甚少。近年来，随着组胺及其受体的不断研究，发现它们对免疫功能起着重要的调节作用。尤其是新的组胺受体4（histamine H4 recptor，H4R）的发现和研究，证明其对免疫系统的调节至关重要。这些研究确定了先前不能解释的变态反应炎症和自身免疫性疾病的机制。H4R 可能成为免疫系统调节新的治疗靶点。
在醫學和生物學意義上，組胺是一種重要的生物胺類物質，但它在變態反應性疾病和自身免疫性疾病中的作用仍然知之甚少。近年來，隨著組胺及其受體的不斷研究，髮現它們對免疫功能起著重要的調節作用。尤其是新的組胺受體4（histamine H4 recptor，H4R）的髮現和研究，證明其對免疫繫統的調節至關重要。這些研究確定瞭先前不能解釋的變態反應炎癥和自身免疫性疾病的機製。H4R 可能成為免疫繫統調節新的治療靶點。
재의학화생물학의의상，조알시일충중요적생물알류물질，단타재변태반응성질병화자신면역성질병중적작용잉연지지심소。근년래，수착조알급기수체적불단연구，발현타문대면역공능기착중요적조절작용。우기시신적조알수체4（histamine H4 recptor，H4R）적발현화연구，증명기대면역계통적조절지관중요。저사연구학정료선전불능해석적변태반응염증화자신면역성질병적궤제。H4R 가능성위면역계통조절신적치료파점。
Histamine is one of the most important biogenic amines in medicine and biology but its role in allergy and autoimmune has not yet been fully defined. The last few years have brought many discoveries concerning important modulatory effects of histamine and its receptors on basic mechanisms of the immunological processes. The immunomodulatory function of a newly described histamine H4 receptor has been revealed. One of the most important modulatory effects of the histamine currently studied is its influence on immunology. These include finding of previous unappreciated mechanism through which histamine regulated inflammation in allergy, as well as autoimmunity. The H4 histamine receptor has become a major target of novel therapeutics.
