中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2013年
23期
9-11
,共3页
沈晓丽%林赛梅%韩莉莉%赖力%陈点%王尧城%刘小晴%浦晓东
瀋曉麗%林賽梅%韓莉莉%賴力%陳點%王堯城%劉小晴%浦曉東
침효려%림새매%한리리%뢰력%진점%왕요성%류소청%포효동
高敏肌钙蛋白T%急性冠脉综合征%诊断阈值%危急界限值
高敏肌鈣蛋白T%急性冠脈綜閤徵%診斷閾值%危急界限值
고민기개단백T%급성관맥종합정%진단역치%위급계한치
Acute coronary syndrome%CTnT-hs%Cutoff value%Critical value
目的：探讨高敏肌钙蛋白T对急性冠脉综合征（ACS）诊断及其危急值的的临界值（cutoff）。方法采用化学发光法检测857例研究对象，其中307例ACS患者和550例正常对照者血浆高敏心肌肌钙蛋白T（cTnT-hs）和高敏心肌肌钙蛋白I（cTnI-hs），应用受试者工作特征曲线（ROC）进行分析。结果cTnT-hs为0.030ng/mL时，其诊断ACS的ROC曲线下面积为0.912，敏感度为89.6%，特异度为83.8%，阴性预测值为92.6%，阳性预测值为94.4%，正确诊断指数为0.734。当以cTnT-hs为0.10ng/mL作为ACS危急界限值时，ROC曲线下面积为0.927，敏感度为90.9%，特异度为87.9%，阴性预测值为89.3%，阳性预测值为86.5%，正确诊断指数为0.788。结论cTnT-hs是诊断ACS敏感而特异的指标，当cutoff值分别为0.03ng/mL、0.10ng/mL时，cTnT-hs诊断ACS及其危急值的cutoff值综合评价最佳。
目的：探討高敏肌鈣蛋白T對急性冠脈綜閤徵（ACS）診斷及其危急值的的臨界值（cutoff）。方法採用化學髮光法檢測857例研究對象，其中307例ACS患者和550例正常對照者血漿高敏心肌肌鈣蛋白T（cTnT-hs）和高敏心肌肌鈣蛋白I（cTnI-hs），應用受試者工作特徵麯線（ROC）進行分析。結果cTnT-hs為0.030ng/mL時，其診斷ACS的ROC麯線下麵積為0.912，敏感度為89.6%，特異度為83.8%，陰性預測值為92.6%，暘性預測值為94.4%，正確診斷指數為0.734。噹以cTnT-hs為0.10ng/mL作為ACS危急界限值時，ROC麯線下麵積為0.927，敏感度為90.9%，特異度為87.9%，陰性預測值為89.3%，暘性預測值為86.5%，正確診斷指數為0.788。結論cTnT-hs是診斷ACS敏感而特異的指標，噹cutoff值分彆為0.03ng/mL、0.10ng/mL時，cTnT-hs診斷ACS及其危急值的cutoff值綜閤評價最佳。
목적：탐토고민기개단백T대급성관맥종합정（ACS）진단급기위급치적적림계치（cutoff）。방법채용화학발광법검측857례연구대상，기중307례ACS환자화550례정상대조자혈장고민심기기개단백T（cTnT-hs）화고민심기기개단백I（cTnI-hs），응용수시자공작특정곡선（ROC）진행분석。결과cTnT-hs위0.030ng/mL시，기진단ACS적ROC곡선하면적위0.912，민감도위89.6%，특이도위83.8%，음성예측치위92.6%，양성예측치위94.4%，정학진단지수위0.734。당이cTnT-hs위0.10ng/mL작위ACS위급계한치시，ROC곡선하면적위0.927，민감도위90.9%，특이도위87.9%，음성예측치위89.3%，양성예측치위86.5%，정학진단지수위0.788。결론cTnT-hs시진단ACS민감이특이적지표，당cutoff치분별위0.03ng/mL、0.10ng/mL시，cTnT-hs진단ACS급기위급치적cutoff치종합평개최가。
Objective To investigate the value of cardiac cTnT-hs in diagnosing acute coronary syndrome(ACS)and determination of its critical value. Methods Plasma cTnT-hs and cTnI-hs levels were measured by electrochemistry immunity illumination method. The receiver operating characteristic curves (ROC) were used to analyze the levels of cTnT-hs in plasma of 307 ACS patients and 550 normal controls. Results At a cutoff point of 0.030ng/mL, the area under ROC curve, sensitivity, specificity, negative predictive value, positive predictive value and Youden's index of cTnT-hs For dignosis of ACS were0.912, 89.6%, 83.8%, 92.6%, 94.4% and 0.734, respectively. While the cutoff point of ACS critical value was 0.10ng/Ml, the area under ROC curve, sensitivity, specificity, negative predictive value, positive predictive value and Youden's index of cTnT-hs were 0.927, 90.9%, 87.9%, 89.3%, 86.5% and 0.788, respectively. Conclusion cTnT is approved to be a sensitive and specific marker in the diagnosis of ACS.While at the cutoff of 0.03, 0.10ng/mL respectively, cTnT-hs has the best evaluation effect in the diagnosis of ACS and determining the cutoff of critical value.
