中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2013年
23期
141-142
,共2页
自身免疫性甲状腺疾病%甲状腺疾病%甲状腺过氧化物酶抗体
自身免疫性甲狀腺疾病%甲狀腺疾病%甲狀腺過氧化物酶抗體
자신면역성갑상선질병%갑상선질병%갑상선과양화물매항체
Autoimmune thyroid disease%Thyroid diseases%Thyroid peroxidase antibody
目的：观察不同甲状腺疾病以及自身免疫性甲状腺疾病（AITD）不同临床阶段患者血清甲状腺过氧化物酶抗体（TPOAb）浓度的变化，进而探讨其临床应用价值。方法选取2012年3月~2013年3月在本院内科住院治疗的甲状腺疾病患者共175例，其中结节性甲状腺肿38例、弥漫性毒性甲状腺肿37例、单纯性甲状腺肿35例、亚急性甲状腺炎10例、慢性淋巴细胞性甲状腺炎45例、甲状腺良性肿瘤10例；取健康志愿者35例作为对照组。通过化学发光法测定各组TPOAb以及不同组患者血清中TPOAb的浓度及阳性发生率。结果结节性甲状腺肿、单纯性甲状腺肿与弥漫性毒性甲状腺肿患者血清中TPOAb浓度及阳性率均高于亚急性甲状腺炎和慢性淋巴细胞性甲状腺炎患者，差异有统计学意义（P＜0.05）。与对照组比较，差异有统计学意义（P＜0.05）。结论ATD患者中的TPOAb浓度明显升高，TPOAb浓度大小对对ATD的诊断有一定的参考价值。
目的：觀察不同甲狀腺疾病以及自身免疫性甲狀腺疾病（AITD）不同臨床階段患者血清甲狀腺過氧化物酶抗體（TPOAb）濃度的變化，進而探討其臨床應用價值。方法選取2012年3月~2013年3月在本院內科住院治療的甲狀腺疾病患者共175例，其中結節性甲狀腺腫38例、瀰漫性毒性甲狀腺腫37例、單純性甲狀腺腫35例、亞急性甲狀腺炎10例、慢性淋巴細胞性甲狀腺炎45例、甲狀腺良性腫瘤10例；取健康誌願者35例作為對照組。通過化學髮光法測定各組TPOAb以及不同組患者血清中TPOAb的濃度及暘性髮生率。結果結節性甲狀腺腫、單純性甲狀腺腫與瀰漫性毒性甲狀腺腫患者血清中TPOAb濃度及暘性率均高于亞急性甲狀腺炎和慢性淋巴細胞性甲狀腺炎患者，差異有統計學意義（P＜0.05）。與對照組比較，差異有統計學意義（P＜0.05）。結論ATD患者中的TPOAb濃度明顯升高，TPOAb濃度大小對對ATD的診斷有一定的參攷價值。
목적：관찰불동갑상선질병이급자신면역성갑상선질병（AITD）불동림상계단환자혈청갑상선과양화물매항체（TPOAb）농도적변화，진이탐토기림상응용개치。방법선취2012년3월~2013년3월재본원내과주원치료적갑상선질병환자공175례，기중결절성갑상선종38례、미만성독성갑상선종37례、단순성갑상선종35례、아급성갑상선염10례、만성림파세포성갑상선염45례、갑상선량성종류10례；취건강지원자35례작위대조조。통과화학발광법측정각조TPOAb이급불동조환자혈청중TPOAb적농도급양성발생솔。결과결절성갑상선종、단순성갑상선종여미만성독성갑상선종환자혈청중TPOAb농도급양성솔균고우아급성갑상선염화만성림파세포성갑상선염환자，차이유통계학의의（P＜0.05）。여대조조비교，차이유통계학의의（P＜0.05）。결론ATD환자중적TPOAb농도명현승고，TPOAb농도대소대대ATD적진단유일정적삼고개치。
Objective To observe the change of serum thyroid peroxidase antibody (TPOAb) concentration in patients with different thyroid diseases and different clinical stages of autoimmune thyroid disease(AITD), and explore its clinical application value. Methods 175 inpatients with thyroid diseases who were treated in department of internal medicine in our hospital from March 2012 to March 2013 were selected, including 38 cases of nodular goiter, 37 cases of diffuse toxic goiter, 35 cases of simple goiter, 10 cases of subacute thyroiditis, 45 cases of chronic lymphocytic thyroiditis, 10 cases of benign thyroid tumor; 35 healthy volunteers were as the control group. The concentration and positive incidence of serum TPOAb of patients in different groups were determined by using the chemiluminescence method. Results The concentration and positive incidence of serum TPOAb in patients with nodular goiter, or simple goiter, or diffuse toxic goiter was significantly higher than that in patients with subacute thyroiditis, or chronic lymphocytic thyroiditis, the difference was statistically significant(P < 0.05). And compared with the control group, the difference was statistically significant(P < 0.05). Conclusion The concentration of TPOAb in ATD patients is significantly higher, and has some reference value in the diagnosis of ATD.
