中华实验和临床感染病杂志（电子版）
中華實驗和臨床感染病雜誌（電子版）
중화실험화림상감염병잡지（전자판）
CHINESE JOURNAL OF EXPERIMENTAL AND CLINICAL INFECTIOUS DISEASES(ELECTRONIC VERSION)
2013年
5期
650-653
,共4页
陈婵%李孟英%谭可平%甘琼萍%陆晖%沈扬林%覃国琦
陳嬋%李孟英%譚可平%甘瓊萍%陸暉%瀋颺林%覃國琦
진선%리맹영%담가평%감경평%륙휘%침양림%담국기
人类免疫缺陷病毒%艾滋病%白细胞介素-17%白细胞介素-23%机会性感染
人類免疫缺陷病毒%艾滋病%白細胞介素-17%白細胞介素-23%機會性感染
인류면역결함병독%애자병%백세포개소-17%백세포개소-23%궤회성감염
Human immunodeficiency virus%Acquired immunodeficiency syndrome%Interleukin-17%Interleukin -23%Opportunistic infections
目的：检测人类免疫缺陷病毒感染者和艾滋病（AIDS）患者血清白细胞介素-17（IL-17）、白细胞介素-23（IL-23）水平，探讨其与患者发生机会性致病菌感染的关系。方法55例AIDS患者，应用ELISA法检测血清IL-17、IL-23水平，结合其临床资料分析与机会性感染的关系。结果55例患者中有44例发现机会性致病菌感染，11例未发生机会性致病菌感染。感染组IL-17水平较非感染组高[（92.53±158.45）pg/ml vs （10.21±19.17）pg/ml，P ＜0.01]，血清IL-23水平差异无统计学意义。12例肺孢子菌感染者的IL-17水平较未感染者明显降低[（19.78±27.95）pg/ml vs （91.78±160.78）pg/ml，P ＜0.01]。血清IL-17、IL-23水平与疾病预后无关。结论 IL-17可能参与HIV/AIDS患者发生机会性感染的免疫机制，低IL-17水平可能导致患者对肺孢子菌的清除能力下降。
目的：檢測人類免疫缺陷病毒感染者和艾滋病（AIDS）患者血清白細胞介素-17（IL-17）、白細胞介素-23（IL-23）水平，探討其與患者髮生機會性緻病菌感染的關繫。方法55例AIDS患者，應用ELISA法檢測血清IL-17、IL-23水平，結閤其臨床資料分析與機會性感染的關繫。結果55例患者中有44例髮現機會性緻病菌感染，11例未髮生機會性緻病菌感染。感染組IL-17水平較非感染組高[（92.53±158.45）pg/ml vs （10.21±19.17）pg/ml，P ＜0.01]，血清IL-23水平差異無統計學意義。12例肺孢子菌感染者的IL-17水平較未感染者明顯降低[（19.78±27.95）pg/ml vs （91.78±160.78）pg/ml，P ＜0.01]。血清IL-17、IL-23水平與疾病預後無關。結論 IL-17可能參與HIV/AIDS患者髮生機會性感染的免疫機製，低IL-17水平可能導緻患者對肺孢子菌的清除能力下降。
목적：검측인류면역결함병독감염자화애자병（AIDS）환자혈청백세포개소-17（IL-17）、백세포개소-23（IL-23）수평，탐토기여환자발생궤회성치병균감염적관계。방법55례AIDS환자，응용ELISA법검측혈청IL-17、IL-23수평，결합기림상자료분석여궤회성감염적관계。결과55례환자중유44례발현궤회성치병균감염，11례미발생궤회성치병균감염。감염조IL-17수평교비감염조고[（92.53±158.45）pg/ml vs （10.21±19.17）pg/ml，P ＜0.01]，혈청IL-23수평차이무통계학의의。12례폐포자균감염자적IL-17수평교미감염자명현강저[（19.78±27.95）pg/ml vs （91.78±160.78）pg/ml，P ＜0.01]。혈청IL-17、IL-23수평여질병예후무관。결론 IL-17가능삼여HIV/AIDS환자발생궤회성감염적면역궤제，저IL-17수평가능도치환자대폐포자균적청제능력하강。
Objective To investigate the relationship between opportunistic infections of HIV/AIDS patients and the serum levels of interleukin-17 (IL-17) and interleukin-23 (IL-23). Methods The serum samples and the clinical information of 55 cases with HIV infection or AIDS patients were collected. The serum concentrations of IL-17 and IL-23 were measured with enzyme linked immunosorbent assay (ELISA). Results There were 44 cases suffering with opportunistic infections in total 55 cases. The serum level of IL-17 in patients with opportunistic infections was significantly higher than that in the group without opportunistic infections [(92.53 ± 158.45) pg/ml vs (10.21 ± 19.17) pg/ml, P < 0.01], but there was no statistical difference in the serum IL-23 concentrations. The serum level of IL-17 in 12 cases with pneumocystis pneumonia was lower than that in the group without pneumocystis pneumonia [(19.78 ± 27.95) pg/ml vs (91.78 ± 160.78) pg/ml, P < 0.01]. The correlation analysis was negative between the prognosis of 55 cases and serum IL-17, IL-23. Conclusions IL-17 may play a role in the immunologic mechanism of HIV/AIDS patients with opportunistic infections. Lower serum IL-17 may result in lower clearance of pneumocystis pneumonia.
