CAJ | 학술논문

目的：了解黄石市手足口病流行期间的病原学特征及流行病学规律，为科学制定手足口病的防控策略提供依据。方法分析本市疾病控制中心2010至2012年手足口病的疫情资料。对2010年1月至2012年12月13734例手足口病病例资料分类统计分析，选取2466例实验室诊断病例进行了病原学分型。结果黄石市手足口病的流行从3月份开始增多，4、5月份急剧上升至高峰，随后逐月下降。2012年11～12月份又出现一个轻微的抬升。3岁以下发病人群中，男女比例为2.08︰1，男性显著性高于女性（χ2=8.36，P ＜0.01），且70%以上为散居儿童。实验室诊断病例病原学分析，2010年手足口病流行以EV71为主导，占44.52%；2011年则以CoxA16为主导，占76.24%；2012年再度以EV71为主导，占98.99%。结论气温和适宜的湿度是手足口病的发生与传播的主要原因，流行时间特征与当地气温和湿度密切相关。EV71和CoxA16为黄石市手足口病流行的两种主要病原体，每年引起流行的病原体呈现交替主导的特征。
목적：료해황석시수족구병류행기간적병원학특정급류행병학규률，위과학제정수족구병적방공책략제공의거。방법분석본시질병공제중심2010지2012년수족구병적역정자료。대2010년1월지2012년12월13734례수족구병병례자료분류통계분석，선취2466례실험실진단병례진행료병원학분형。결과황석시수족구병적류행종3월빈개시증다，4、5월빈급극상승지고봉，수후축월하강。2012년11～12월빈우출현일개경미적태승。3세이하발병인군중，남녀비례위2.08︰1，남성현저성고우녀성（χ2=8.36，P ＜0.01），차70%이상위산거인동。실험실진단병례병원학분석，2010년수족구병류행이EV71위주도，점44.52%；2011년칙이CoxA16위주도，점76.24%；2012년재도이EV71위주도，점98.99%。결론기온화괄의적습도시수족구병적발생여전파적주요원인，류행시간특정여당지기온화습도밀절상관。EV71화CoxA16위황석시수족구병류행적량충주요병원체，매년인기류행적병원체정현교체주도적특정。
Objective To investigate the epidemic features and etiology of hand, foot and mouth disease (HFMD) and provide scientific basis for making preventive and control measures of HFMD. Methods Total of 13 734 cases were investigated from January 2010 to December 2012 in Huangshi. Enterovirus universal type (pan-EV),enterovirus 71 (EV71) and Coxsackie virus A16 (CoxA 16) were detected by real-time RT-PCR, respectively. Results The peak of HFMD incidence was detected from April to June, accounting for 67.12%, 32.58% and 77.74%, respectively. Among the reported cases, 87.15% were children less than 3 years old and 70% were the scattered children. There was a significant more of HFMD in boys compared with girls (χ2 = 8.36,P < 0.01). The majority of the pathogen was CoxA16 in 2011 and EV71 was predominant in 2010 and 2012. Conclusions The warmer climate and favourable humidity could incease the likelyhood of HFMD spread and transmission. Prompt epidemical investigation of HFMD and prediction of spreading features is helpful for making better measures for the prevention and control of the disease.