CAJ | 학술논문

目的：探讨大蒜素对幽门螺杆菌（HP）阴性慢性萎缩性胃炎的治疗作用。方法采用前瞻性、自身对照方法，选择2010年1月至2012年6月于本院经胃镜加病理确诊的慢性萎缩性胃炎并HP阴性患者，共69例，所有患者常规服用大蒜素24周。对治疗前、治疗12、24周分别进行临床症状评分，治疗前、治疗24周分别行胃镜检查并取标本行组织病理检查，比较治疗前后的变化。结果治疗12、24周患者较治疗前临床症状评分下降，差异均具有统计学意义（P均＜0.05）；治疗24周后较治疗前内镜下表现、组织病理评分均有明显改善，差异具有统计学意义（P均＜0.05）。结论大蒜素可显著改善HP阴性慢性萎缩性胃炎患者的临床症状、内镜下表现及组织病理情况，值得临床进一步研究。
목적：탐토대산소대유문라간균（HP）음성만성위축성위염적치료작용。방법채용전첨성、자신대조방법，선택2010년1월지2012년6월우본원경위경가병리학진적만성위축성위염병HP음성환자，공69례，소유환자상규복용대산소24주。대치료전、치료12、24주분별진행림상증상평분，치료전、치료24주분별행위경검사병취표본행조직병리검사，비교치료전후적변화。결과치료12、24주환자교치료전림상증상평분하강，차이균구유통계학의의（P균＜0.05）；치료24주후교치료전내경하표현、조직병리평분균유명현개선，차이구유통계학의의（P균＜0.05）。결론대산소가현저개선HP음성만성위축성위염환자적림상증상、내경하표현급조직병리정황，치득림상진일보연구。
Objective To explore the therapeutic effects of the allicin on patients with chronic atrophic gastritis (CAG) of Helicobacter pylori (HP) negative. Methods By prospective, self-control study, total of 69 patients with HP negative CAG diagnosed by the gastroscopy and pathological examination were investigated in Qingdao Municipal Hospital during January 2010 to June 2012, and all the patients took allicin for 24 weeks. The clinical symptoms before treatment and 12, 24 weeks after therapy were evaluated, and findings of gastroscopy and histology of gastric mucosa were recorded and compared before and after the treatment. Results Clinical symptom scores decreased after 12 and 24 weeks of treatment than before, with significant difference (P < 0.05). The endoscopic performance, the pathology score were all improved before and after therapy, with significant difference (P < 0.05). Conclusions Allicin could significantly improve the clinical symptoms, endoscopic performance and pathological situation of CAG patients with HP negative, worthy of further clinical research.