医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2013年
6期
23-26
,共4页
范克满%王世富%王素兰%贾云霞%蒋芙蓉%于凤玲%张乐海
範剋滿%王世富%王素蘭%賈雲霞%蔣芙蓉%于鳳玲%張樂海
범극만%왕세부%왕소란%가운하%장부용%우봉령%장악해
NICU%病原菌%肺炎克雷伯杆菌%耐药性
NICU%病原菌%肺炎剋雷伯桿菌%耐藥性
NICU%병원균%폐염극뢰백간균%내약성
NICU%Pathogenic bacteria%Klebsiella pneumoniae%Resistance
目的：了解NICU病房病原菌的分布及耐药性特点,为NICU感染的临床治疗提供依据，以指导临床合理用药，并为院内感染控制提供理论支持。方法：严格按照《全国临床检验操作规程》对NICU病房的标本进行进行分离及鉴定，采用K-B法进行药敏试验，应用WHONET5和SPSS10.0进行统计分析。结果：NICU科分离的69株肺炎克雷伯菌耐药性较强，其对头孢哌酮/舒巴坦、头孢吡肟、头孢他啶的敏感分别为44.9%、7.2%、7.2%，远低于我院其他科室分离的肺炎克雷伯菌对这三种药物敏感性的平均值（分别为64.6%、36%、33.6%），具有显著性差异；但其对亚胺培南和美洛培南的敏感率无显著性差异。结论：NICU感染的肺炎克雷伯菌可能来自分娩时母体（即成人感染的肺炎克雷伯菌），其对头孢哌酮/舒巴坦、头孢吡肟、头孢他啶敏感性较儿童感染的肺炎克雷伯菌的敏感性明显降低，临床微生物室应加强NICU肺炎克雷伯杆菌的检测工作，NICU分离到的肺炎克雷伯菌的药敏的差异值得引起NICU科大夫的注意。
目的：瞭解NICU病房病原菌的分佈及耐藥性特點,為NICU感染的臨床治療提供依據，以指導臨床閤理用藥，併為院內感染控製提供理論支持。方法：嚴格按照《全國臨床檢驗操作規程》對NICU病房的標本進行進行分離及鑒定，採用K-B法進行藥敏試驗，應用WHONET5和SPSS10.0進行統計分析。結果：NICU科分離的69株肺炎剋雷伯菌耐藥性較彊，其對頭孢哌酮/舒巴坦、頭孢吡肟、頭孢他啶的敏感分彆為44.9%、7.2%、7.2%，遠低于我院其他科室分離的肺炎剋雷伯菌對這三種藥物敏感性的平均值（分彆為64.6%、36%、33.6%），具有顯著性差異；但其對亞胺培南和美洛培南的敏感率無顯著性差異。結論：NICU感染的肺炎剋雷伯菌可能來自分娩時母體（即成人感染的肺炎剋雷伯菌），其對頭孢哌酮/舒巴坦、頭孢吡肟、頭孢他啶敏感性較兒童感染的肺炎剋雷伯菌的敏感性明顯降低，臨床微生物室應加彊NICU肺炎剋雷伯桿菌的檢測工作，NICU分離到的肺炎剋雷伯菌的藥敏的差異值得引起NICU科大伕的註意。
목적：료해NICU병방병원균적분포급내약성특점,위NICU감염적림상치료제공의거，이지도림상합리용약，병위원내감염공제제공이론지지。방법：엄격안조《전국림상검험조작규정》대NICU병방적표본진행진행분리급감정，채용K-B법진행약민시험，응용WHONET5화SPSS10.0진행통계분석。결과：NICU과분리적69주폐염극뢰백균내약성교강，기대두포고동/서파탄、두포필우、두포타정적민감분별위44.9%、7.2%、7.2%，원저우아원기타과실분리적폐염극뢰백균대저삼충약물민감성적평균치（분별위64.6%、36%、33.6%），구유현저성차이；단기대아알배남화미락배남적민감솔무현저성차이。결론：NICU감염적폐염극뢰백균가능래자분면시모체（즉성인감염적폐염극뢰백균），기대두포고동/서파탄、두포필우、두포타정민감성교인동감염적폐염극뢰백균적민감성명현강저，림상미생물실응가강NICU폐염극뢰백간균적검측공작，NICU분리도적폐염극뢰백균적약민적차이치득인기NICU과대부적주의。
Objective:To understand the NICU ward of the pathogen distribution and drug resistance characteristic, for the clinical treatment of NICU infection provides the basis, to guide clinical rational drug use, and for nosocomial infection control to provide theory support. Methods:In strict accordance with the national clinical inspection operating rules of NICU ward of specimens from separation and identification, and adopts k-b method of drug sensitive test, the application WHONET5 SPSS10.0 and statistical analysis.Results:69 strains separated NICU pneumonia clay "bacteria strong resistance, on the cefoperazone/sulbactam , cefepime, cefotaxime sensitive were 44.9%, 7.2%, 7.2%, much lower than other department of our separation of this bacteria pneumonia clay"three drugs sensitivity average (were 64.6%, 36%, 33.6%), has a significant difference; But its imipenem and culture of south los sensitive rate no significant differences. Conclusions:NICU pneumonia clay"may come from bacteria during the matrix (i.e. adult pneumonia clay"bacteria), the cefoperazone/sulbactam was, cefepime, cefotaxime sensitivity than children pneumonia clay"bacteria to the sensitivity of the reduced significantly, and clinical microbial room should strengthen the NICU pneumonia clay" bacillus testing work, NICU from pneumonia clay"bacteria medicine quick difference is worth causing the NICU, the attention of the doctor.
