CAJ | 학술논문

目的：研究不同时期增生性瘢痕患者血清中PⅢN P浓度变化的意义及其对临床瘢痕治疗的指导意义。方法：选择2010年9月-2012年9月我科收治住院的增生性瘢痕患者共100例，根据瘢痕增生的不同时期分5组。应用ELISA法检测患者血清中Ⅲ型前胶原氨基端肽(PⅢNP)的浓度变化，并比较PⅢN P的血清含量与瘢痕增生时段之间的关系。结果：不同时期增生性瘢痕患者血清中PⅢN P含量和瘢痕增生时段关系密切，瘢痕增生早期，1-4个月患者血清中PⅢN P含量开始增加，随着增生性瘢痕的发展，其血清含量进一步的增加，到5-8个月，PⅢN P含量达到了高峰。伴随瘢痕的成熟，PⅢN P浓度又逐渐下降。结论：PⅢNP的浓度变化和瘢痕临床演进过程基本一致。同时证明了增生性瘢痕增生活跃程度与瘢痕患者血清中PⅢNP的浓度呈定量的显著关系，可以作为临床不同的瘢痕治疗方法的疗效评价及筛选的客观指标，具有指导意义。
목적：연구불동시기증생성반흔환자혈청중PⅢN P농도변화적의의급기대림상반흔치료적지도의의。방법：선택2010년9월-2012년9월아과수치주원적증생성반흔환자공100례，근거반흔증생적불동시기분5조。응용ELISA법검측환자혈청중Ⅲ형전효원안기단태(PⅢNP)적농도변화，병비교PⅢN P적혈청함량여반흔증생시단지간적관계。결과：불동시기증생성반흔환자혈청중PⅢN P함량화반흔증생시단관계밀절，반흔증생조기，1-4개월환자혈청중PⅢN P함량개시증가，수착증생성반흔적발전，기혈청함량진일보적증가，도5-8개월，PⅢN P함량체도료고봉。반수반흔적성숙，PⅢN P농도우축점하강。결론：PⅢNP적농도변화화반흔림상연진과정기본일치。동시증명료증생성반흔증생활약정도여반흔환자혈청중PⅢNP적농도정정량적현저관계，가이작위림상불동적반흔치료방법적료효평개급사선적객관지표，구유지도의의。
Objective To research the dose and the significances of amino-terminal propeptide of procol agen type Ⅲ (PⅢNP) in the serum of hypertrophic scar patients at excessive stages and favor making therapeutic regimen to cure hypertrophic scar. Methods Col ect the serum samples of 100 cases inpatients admitted in our hospital from 2010,9 to 2012,9 suffering from long-persisting post-burned hypertrophic scar at various stages. Hypertrophic scar patients are divided into 5 groups according to the phase of scar and detect the concentrations of PⅢNP in serum of the trials using the sensitive ELISA method and analysis the relation between the doses of PⅢNP and proliferation degree of the scar. Results The dose of PⅢNP begin to rise in 1 to 4 months scar group and increases gradual y during the process of immature hypertrophic scar to mature scar before it achieves summit concentration in 5 to 8 months scar group. The concentration of PⅢNP degreases gradual y with the maturation of hypertrophic scar. Conclusions The dose of PⅢNP is synonymous with the ongoing process of hypertrophic scar. PⅢNP may be a satisfactory marker in discerning the growth and development of post-burn hypertrophic scar and have great significance to guide our clinical treatment to cure hypertrophic scars. The change of the dose of PⅢNP in serum of hypertrophic scar patients can be taken as standard to evaluate curative effect of different therapies and can be used for rapid screening favorable curative methods.