CAJ | 학술논문

目的：对比分析阿德福韦酯与拉米夫定治疗乙型肝炎肝纤维化的临床效果。方法选取我院自2006年10月至2012年10月期间收治的乙型肝炎肝纤维化患者98例，作为临床研究对象。将所有患者进行随机分组，每组各49例，试验组患者采用阿德福韦酯治疗，对照组患者采用拉米夫定治疗。记录并比较两组患者治疗15个月后 Child-Pugh 分级评情况。结果试验组患者治疗后 Child-Pugh 分级评分明显优于对照组，A 级得分人数比例（83.67%）明显高对照组（67.35%），P ＜0.05，具有统计学意义。结论临床上采用阿德福韦酯治疗乙型肝炎肝纤维化优势明显，疗效优于拉米夫定治疗组，不良反应发生少，患者肝功能指标情况良好，有一定的临床优势，值得推广使用。
목적：대비분석아덕복위지여랍미부정치료을형간염간섬유화적림상효과。방법선취아원자2006년10월지2012년10월기간수치적을형간염간섬유화환자98례，작위림상연구대상。장소유환자진행수궤분조，매조각49례，시험조환자채용아덕복위지치료，대조조환자채용랍미부정치료。기록병비교량조환자치료15개월후 Child-Pugh 분급평정황。결과시험조환자치료후 Child-Pugh 분급평분명현우우대조조，A 급득분인수비례（83.67%）명현고대조조（67.35%），P ＜0.05，구유통계학의의。결론림상상채용아덕복위지치료을형간염간섬유화우세명현，료효우우랍미부정치료조，불량반응발생소，환자간공능지표정황량호，유일정적림상우세，치득추엄사용。
Objective To compare and analyse the clinical effects of adefovir dipivoxil and lamivudine(LAM) on liver fibrosis of hepatitis B. Methods 98 patients with liver fibrosis of hepatitis B in our hospital from October 2006 to October 2012 were selected as clinical study objects. All patients were randomly divided into two group, 49 cases in each group, the experimental group were treated with adefovir dipivoxil,the control group were treated with lamivudine. Recorded and compared the Child-Pugh grading-score conditions of two group patients after 15 months of treatment. Results The Child-Pugh grading-score of experimental group patients after treatment were significantly better than the control group,and the A score percentage of experimental group (83.67 %) was significantly higher than control group (67.35 %),P<0.05,the results were statistically significant. Conclusions It has obvious advantages to apply adefovir dipivoxil in the treatment of liver fibrosis of hepatitis B in clinic, which is more effective than lamivudine treatment group, with fewer adverse reactions, liver function indexes of patients is good , having certain clinical advantages, it should be promoted.