CAJ | 학술논문

目的：观察黄芪注射液对地塞米松（Dex）所致免疫功能低下小鼠T细胞增殖的影响。方法连续腹腔注射给药5天，末次给药后2h称小鼠体重。结果与对照组相比，模型组小鼠胸腺指数、血清与胸腺IL-2的含量均有显著减少（P＜0.05），而胸腺PCNA表达面积累积百分比无显著差异（P＞0.05）。结论黄芪注射液可抑制Dex所致免疫功能低下模型小鼠的胸腺萎缩，促进免疫功能的恢复。
목적：관찰황기주사액대지새미송（Dex）소치면역공능저하소서T세포증식적영향。방법련속복강주사급약5천，말차급약후2h칭소서체중。결과여대조조상비，모형조소서흉선지수、혈청여흉선IL-2적함량균유현저감소（P＜0.05），이흉선PCNA표체면적루적백분비무현저차이（P＞0.05）。결론황기주사액가억제Dex소치면역공능저하모형소서적흉선위축，촉진면역공능적회복。
Objective To observe the effect of astragalus injection of dexamethasone(Dex) proliferation induced immunosuppressed mice T cels.Methods Besides control group,the other five groups were injected Dex 5 days for immunodeficient mice model,two hours after the final injection,weight recorded.Results Compared with the control group, thymus index and IL-2 of serum and thymus homogenate in model group were significantly reduced(P<0.05),but protein expression of PCNA had no significant difference(P>0.05).Conclusion Immunity was impaired in mice exposed to Dex,AI could play an important role in recovering the immune function,the mechanisms would be further researched.