中国药物经济学
中國藥物經濟學
중국약물경제학
CHINA JOURNAL OF PHARMACEUTICAL ECONOMICS
2014年
1期
61-63
,共3页
还原型谷胱甘肽钠%磷酸肌酸钠%血清肌钙蛋白%肌酸激酶同工酶%心肌损伤
還原型穀胱甘肽鈉%燐痠肌痠鈉%血清肌鈣蛋白%肌痠激酶同工酶%心肌損傷
환원형곡광감태납%린산기산납%혈청기개단백%기산격매동공매%심기손상
Reduced Glutathione sodium%Creatine Phosphate Sodium%cTnI%CK-MB%Myocardial damage
目的：观察还原型谷胱甘肽钠、磷酸肌酸钠治疗新生儿窒息后心肌损伤的疗效。方法将78例新生儿窒息致心肌损伤患儿随机分为还原型谷胱甘肽钠组、磷酸肌酸钠组和对照组。三组均给予常规治疗，还原型谷胱甘肽钠组静脉泵入还原型谷胱甘肽钠，磷酸肌酸钠组静脉泵入磷酸肌酸钠，对照组加用大剂量维生素C 250mg/kg。观察三组患儿治疗前、后症状、体征以及血清肌钙蛋白（cTnI）、肌酸激酶同工酶（CK-MB）的变化。结果还原型谷胱甘肽钠组、磷酸肌酸钠组和对照组治疗前cTnI、CK-MB比较，差异均无统计学意义，治疗后比较，还原型谷胱甘肽钠组和对照组、磷酸肌酸钠组和对照组差异均有统计学意义，还原型谷胱甘肽钠组和磷酸肌酸钠组差异无统计学意义；同组治疗前、后比较，差异均有统计学意义（P＜0.05）；还原型谷胱甘肽钠组、磷酸肌酸钠组的有效率分别为89.7%、84.6%，对照组有效率为60.9%，差异有统计学意义（P＜0.05）。结论还原型谷胱甘肽钠、磷酸肌酸钠治疗新生儿窒息后心肌损伤疗效显著，可明显降低cTnI、CK-MB水平，从而改善心肌损伤。
目的：觀察還原型穀胱甘肽鈉、燐痠肌痠鈉治療新生兒窒息後心肌損傷的療效。方法將78例新生兒窒息緻心肌損傷患兒隨機分為還原型穀胱甘肽鈉組、燐痠肌痠鈉組和對照組。三組均給予常規治療，還原型穀胱甘肽鈉組靜脈泵入還原型穀胱甘肽鈉，燐痠肌痠鈉組靜脈泵入燐痠肌痠鈉，對照組加用大劑量維生素C 250mg/kg。觀察三組患兒治療前、後癥狀、體徵以及血清肌鈣蛋白（cTnI）、肌痠激酶同工酶（CK-MB）的變化。結果還原型穀胱甘肽鈉組、燐痠肌痠鈉組和對照組治療前cTnI、CK-MB比較，差異均無統計學意義，治療後比較，還原型穀胱甘肽鈉組和對照組、燐痠肌痠鈉組和對照組差異均有統計學意義，還原型穀胱甘肽鈉組和燐痠肌痠鈉組差異無統計學意義；同組治療前、後比較，差異均有統計學意義（P＜0.05）；還原型穀胱甘肽鈉組、燐痠肌痠鈉組的有效率分彆為89.7%、84.6%，對照組有效率為60.9%，差異有統計學意義（P＜0.05）。結論還原型穀胱甘肽鈉、燐痠肌痠鈉治療新生兒窒息後心肌損傷療效顯著，可明顯降低cTnI、CK-MB水平，從而改善心肌損傷。
목적：관찰환원형곡광감태납、린산기산납치료신생인질식후심기손상적료효。방법장78례신생인질식치심기손상환인수궤분위환원형곡광감태납조、린산기산납조화대조조。삼조균급여상규치료，환원형곡광감태납조정맥빙입환원형곡광감태납，린산기산납조정맥빙입린산기산납，대조조가용대제량유생소C 250mg/kg。관찰삼조환인치료전、후증상、체정이급혈청기개단백（cTnI）、기산격매동공매（CK-MB）적변화。결과환원형곡광감태납조、린산기산납조화대조조치료전cTnI、CK-MB비교，차이균무통계학의의，치료후비교，환원형곡광감태납조화대조조、린산기산납조화대조조차이균유통계학의의，환원형곡광감태납조화린산기산납조차이무통계학의의；동조치료전、후비교，차이균유통계학의의（P＜0.05）；환원형곡광감태납조、린산기산납조적유효솔분별위89.7%、84.6%，대조조유효솔위60.9%，차이유통계학의의（P＜0.05）。결론환원형곡광감태납、린산기산납치료신생인질식후심기손상료효현저，가명현강저cTnI、CK-MB수평，종이개선심기손상。
Objective To observe clinical curative effect of Reduced Glutathione Sodium,Creatine Phosphate Sodium in treatment of myocardial damage after neonatal asphyxia.Methods 78 cases of newborn′s myocardial damage were randomly divided into the Reduced Glutathione Sodium group,Creatine Phosphate Sodium group and control group.The three groups were given normal treatments,the Reduced Glutathione Sodium group were given Reduced Glutathione Sodium through injection,Creatine Phosphate Sodium group were given Creatine Phosphate Sodium through injection,and control group were given large doses vitaminC 250mg/kg.Results Compared with the Reduced Glutathione Sodium group,Creatine Phosphate Sodium group and control group,CK-MB and cTnI before treament were not different,but after treament they were statisticaly significant different(P<0.05);The effective rate of the Reduced Glutathione Sodium group and Creatine Phosphate Sodium group was 89.7%and 84.6%,and of the control group 60.9%,the difference was statisticaly significant(P<0.05).Conclusion Reduced Glutathione sodium and Creatine Phosphate Sodium which can reduce the dose of CK-MB and cTnI have siginificant efffect in myocardial damage after neonatal asphyxia, thus they can improve myocardial damage.
