CAJ | 학술논문

目的：探讨分析乳腺良恶性病变动态增强M RI表现特征与血管内皮生长因子的表达水平以及微血管密度之间的相关性。方法：对40例行动态增强M RI乳腺检查并同时经病理以及免疫组织化学技术确诊患者通过早期增强率、时间-信号强度曲线、强化峰值评价动态增强M RI的表现；病理切片经相关抗原进行免疫组化染色，并测定血管内皮生长因子的表达水平以及微血管密度。结果：40例乳腺疾病患者，24例患者为恶性病变，16例患者为良性病变，恶性病变的血管内皮生长因子的表达水平以及微血管密度均明显高于良性病变（ P＜0．05）。40例乳腺良恶性疾病患者中，早期增强率＞60％的患者与早期增强率＜60％的患者相比较，时间-信号强度曲线以及血管内皮生长因子的表达水平之间的差异（P＞0．05）；而强化峰值、微血管密度之间有显著性差异（P＜0．05）。结论：乳腺良恶性疾病动态增强M RI表现特征与血管内皮生长因子的表达水平以及微血管密度密切相关。
목적：탐토분석유선량악성병변동태증강M RI표현특정여혈관내피생장인자적표체수평이급미혈관밀도지간적상관성。방법：대40례행동태증강M RI유선검사병동시경병리이급면역조직화학기술학진환자통과조기증강솔、시간-신호강도곡선、강화봉치평개동태증강M RI적표현；병리절편경상관항원진행면역조화염색，병측정혈관내피생장인자적표체수평이급미혈관밀도。결과：40례유선질병환자，24례환자위악성병변，16례환자위량성병변，악성병변적혈관내피생장인자적표체수평이급미혈관밀도균명현고우량성병변（ P＜0．05）。40례유선량악성질병환자중，조기증강솔＞60％적환자여조기증강솔＜60％적환자상비교，시간-신호강도곡선이급혈관내피생장인자적표체수평지간적차이（P＞0．05）；이강화봉치、미혈관밀도지간유현저성차이（P＜0．05）。결론：유선량악성질병동태증강M RI표현특정여혈관내피생장인자적표체수평이급미혈관밀도밀절상관。
Objective:To investigate the analysis of benign and malignant breast lesions characteristic dy-namic contrast enhanced MRI and vascular endothelial growth factor expression levels as well as the correlation be-tween microvessel density .Methods :The subjects were 40 patients in our hospital dynamic enhanced MRI breast examination and also by pathological and immunohistochemical diagnosis of patients .Through early enhancement ra-tio ,time-signal intensity curve ,peak enhancement evaluate the performance of dynamic contrast-enhanced M RI ;pathology associated antigens by immunohistochemistry ,and serum vascular endothelial grow th factor expression and microvessel density .Results :40 cases of breast disease ,malignant lesions in 24 patients ,16 patients with be-nign lesions and malignant lesions of the vascular endothelial growth factor expression and microvessel density were significantly higher than benign lesions ,the difference (P <0 .05) ,with statistical significance .40 cases of benign and malignant breast disease patients ,early enhancement rate> 60% of patients with early enhancement rate <60%of patients compared with time-signal intensity curve ,and vascular endothelial growth factor in the difference be-tween the expression levels (P> 0 .05 ) ,was not statistically significant ;while peak enhancement ,the difference between microvessel density (P <0 .05) ,with statistical significance .Conclusion:benign and malignant breast le-sions characteristic dynamic contrast enhanced MRI and vascular endothelial growth factor expression and microves-sel density levels are closely related .