CAJ | 학술논문

目的：考察不同条件下白术挥发油中苍术酮的稳定性。方法：采用高效液相色谱法测定挥发油中苍术酮及白术内酯含量，以苍术酮及白术内酯的相对含量作为衡量苍术酮变化的指标。结果：白术挥发油纯品中的苍术酮在室温日光条件下，第6天分解率达到12%以上，在室温避光条件下基本不变。挥发油吐温-80溶液在室温避光条件下，苍术酮在第5天的分解率达到30%以上，在冷冻避光条件下基本不变。挥发油中的苍术酮在人工胃液及人工肠液中均不稳定，其变化符合一级动力学过程。结论：在不同条件下，白术挥发油中苍术酮的稳定性不同，稀溶液中48小时内比较稳定，苍术酮较其纯品稳定性好。
목적：고찰불동조건하백술휘발유중창술동적은정성。방법：채용고효액상색보법측정휘발유중창술동급백술내지함량，이창술동급백술내지적상대함량작위형량창술동변화적지표。결과：백술휘발유순품중적창술동재실온일광조건하，제6천분해솔체도12%이상，재실온피광조건하기본불변。휘발유토온-80용액재실온피광조건하，창술동재제5천적분해솔체도30%이상，재냉동피광조건하기본불변。휘발유중적창술동재인공위액급인공장액중균불은정，기변화부합일급동역학과정。결론：재불동조건하，백술휘발유중창술동적은정성불동，희용액중48소시내비교은정，창술동교기순품은정성호。
This study was aimed to explore the stability of atractylon in volatile oil of A tractylodes macrocephala Koidz. under various conditions. High performance liquid chromatography (HPLC) method was used to determine the atractylon content and atractylenolide content of volatile oils. And the relative percentages of atractylone and a-tractylenolide were selected as indexes to measure the change of atractylon. The results showed that the atractylon in atractylodes volatile oil was unstable with the rate of atractylon decomp osition up to 12% in natural conditions on the 6th day. The condition was almost not changed at room temperature and avoiding light. Atractylodes volatile oil in tween-80 solution was unstable with the rate of atractylon decomposition up to 30% at room temperature and avoiding light on the 5th day. The condition was almost not changed in the freezing temperature and avoiding light. The atracty-lon in volatile oil in artificial gastric juice and artificial intestinal juice were unstable, which were in conformity with the first order kinetics. It was concluded that the stability of atractylon of volatile oil was different. The atractylon of volatile oil was relatively stable in dilute solution within 48 hours. The atractylon in volatile oil was stable than its pure solution.