CAJ | 학술논문

目的：研究保和颗粒对于冠心病慢性心衰（CHF）患者中医证候疗效、胃肠激素分泌的影响。方法：以冠心病慢性心衰患者为研究对象，入选的80例患者分为两组，对照组予西医药抗心衰规范治疗，治疗组在此基础上联合服用保和颗粒，观察用药2周后两组患者在中医证候疗效、症状积分及血清胃泌素、血浆胃动素分泌影响的比较。结果：两组治疗均可明显改善CHF患者的中医证候疗效及症状总积分，且以保和颗粒治疗组疗效更好；同时可明显改善中医单项症状积分，其中以保和颗粒治疗组对于心悸、气短乏力、腹胀、纳呆等症疗效更优；并可提高CHF患者的GAS及MTL水平，而治疗组升高更为明显。结论：在西医药规范治疗基础上合用保和颗粒，可更好的改善CHF患者的中医证候、症状及胃肠激素分泌，从而利于病情的稳定，延缓进展，改善预后，值得在临床上进一步推广。
목적：연구보화과립대우관심병만성심쇠（CHF）환자중의증후료효、위장격소분비적영향。방법：이관심병만성심쇠환자위연구대상，입선적80례환자분위량조，대조조여서의약항심쇠규범치료，치료조재차기출상연합복용보화과립，관찰용약2주후량조환자재중의증후료효、증상적분급혈청위비소、혈장위동소분비영향적비교。결과：량조치료균가명현개선CHF환자적중의증후료효급증상총적분，차이보화과립치료조료효경호；동시가명현개선중의단항증상적분，기중이보화과립치료조대우심계、기단핍력、복창、납태등증료효경우；병가제고CHF환자적GAS급MTL수평，이치료조승고경위명현。결론：재서의약규범치료기출상합용보화과립，가경호적개선CHF환자적중의증후、증상급위장격소분비，종이리우병정적은정，연완진전，개선예후，치득재림상상진일보추엄。
This article was aimed to study the effect of Baohe granules for patients with chronic heart failure (CHF) of traditional Chinese medicine (TCM) syndrome and the effect of gastrointestinal hormone secretion. Patients with CHF were used as the object of study. A total of 80 selected patients were divided into 2 groups. The control group was treated with western medicine anti-heart failure therapy. The treatment group was treated with the combination of Baohe granules. All patients were compared in aspects of TCM efficacy, symptom score and serum gastrin, motilin secretion after two-week medication. The results showed that both treatments can significantly improve the TCM syn-drome and symptom total score of CHF patients. And the effect of the treatment group with Baohe granules was bet-ter. The TCM single symptom integral was also obviously improved in the treatment group combined with Baohe granules, which included heart palpitations, shortness of breath, abdominal distension, and loss of appetite. The GAS and MTL levels of CHF patients were significantly increased in the treatment group. It was concluded that the treat-ment combined with Baohe granules can improve CHF patients with TCM syndromes, symptoms and gastrointestinal hormone secretion. Thus, it contributed to the stability of the disease condition. It can slow the disease progression and improve prognosis. So it is worth using widely in the clinical practice.