CAJ | 학술논문

目的：研究气滞胃痛颗粒组方中促胃肠动力有效组分协同关系及作用机制。方法：将大鼠随机分成16组，分别灌胃给予不同配伍组合促胃肠动力有效组分，应用传统半固体糊碳末推进法观察大鼠用药后的胃肠动力变化；测定胃肠组织中NO、cGMP及Ca2+含量变化。结果：气滞胃痛颗粒中促胃肠动力有效组分以枳壳黄酮和香附黄酮作用显著（P<0.01），香附挥发油和柠檬烯作用明显（P<0.05），两两交互作用表明枳壳黄酮与柠檬烯合用对胃肠动力具有显著促进作用，其次分别为枳壳黄酮与香附挥发油、香附黄酮与挥发油、柠檬烯与香附挥发油合用；各有效组分均能使胃肠组织中NO、cGMP含量降低，Ca2+含量升高。结论：本研究确定了气滞胃痛颗粒各组分与促胃肠动力活性的相关程度及相互间协同作用，其作用机制与胃肠组织中NO、cGMP含量降低，Ca2+含量升高有关，为进一步研究促胃肠动力药效质量控制、配伍及谱效关系提供理论依据。
목적：연구기체위통과립조방중촉위장동력유효조분협동관계급작용궤제。방법：장대서수궤분성16조，분별관위급여불동배오조합촉위장동력유효조분，응용전통반고체호탄말추진법관찰대서용약후적위장동력변화；측정위장조직중NO、cGMP급Ca2+함량변화。결과：기체위통과립중촉위장동력유효조분이지각황동화향부황동작용현저（P<0.01），향부휘발유화저몽희작용명현（P<0.05），량량교호작용표명지각황동여저몽희합용대위장동력구유현저촉진작용，기차분별위지각황동여향부휘발유、향부황동여휘발유、저몽희여향부휘발유합용；각유효조분균능사위장조직중NO、cGMP함량강저，Ca2+함량승고。결론：본연구학정료기체위통과립각조분여촉위장동력활성적상관정도급상호간협동작용，기작용궤제여위장조직중NO、cGMP함량강저，Ca2+함량승고유관，위진일보연구촉위장동력약효질량공제、배오급보효관계제공이론의거。
This article was aimed to study the synergy effect of effective substances group and mechanisms of Qi-Zhi Wei-Tong (QZWT) Granules in promoting gastrointestinal dynamic effect in order to explore its mechanism. Rats were divided into 16 groups. Different component compatibility was given to promote the gastrointestinal dynamic ef-fect. The traditional semi-solid paste carbon propelling analysis method was used to observe gastrointestinal motility changes of rats after medication. After intragastric administration, changes of NO, cGMP and Ca2+content in gastroin-testinal tissues were observed. The results showed that fructus aurantii flavonoids and Cyperi flavonoids had the most prominent effect in promoting gastrointestinal motility in QZWT Granules (P< 0.01), which were followed by Cyperus oil and limonene (P< 0.05). Two-way interactions indicated that the combination of fructus aurantii flavonoids and limonene had prominently promoting action in gastrointestinal motility, which was followed by the combination of fructus aurantii flavonoids and Cyperus oil, Cyperi flavonoids and Cyperus oil, limonene and Cyperus oil. Each effec-tive component can reduce the NO and cGMP content in gastrointestinal tissues, and increase the Ca2+ content. It was concluded that the study defined the correlation and synergy between effective components and promoting effect of gastrointestinal motility. Mechanism of the effective component to promote gastrointestinal dynamic might be relat-ed to the reducing of NO and cGMP content in gastrointestinal tissues and increasing of Ca2+ content. This study also provided a theoretical basis for further research on quality control, compatibility and spectrum-effect correlation of gastrointestinal motility promotion medications.