河北中医
河北中醫
하북중의
HEBEI JORNAL OF TRADITIONAL CHINESE MEDICINE
2014年
1期
11-13,16
,共4页
C反应蛋白质%丹参%心绞痛,不稳定型%中药疗法%药物作用%注射剂
C反應蛋白質%丹參%心絞痛,不穩定型%中藥療法%藥物作用%註射劑
C반응단백질%단삼%심교통,불은정형%중약요법%약물작용%주사제
C-reactive protein%Salvia miltiorrhiza%Angina pectoris%Unstable%Traditional Chinese medi-cine therapy%Drug effects%Injection
目的：观察注射用丹参多酚酸盐对不稳定性心绞痛（ UAP）患者血浆高敏C反应蛋白（ hs-CRP）、肿瘤坏死因子（TNF-α）以及可溶性细胞凋亡因子Fas（sFas）的影响。方法将124例UAP患者随机分为2组。对照组62例予西医常规治疗，治疗组62例在对照组治疗基础上加用注射用丹参多酚酸盐治疗。2组均14 d为1个疗程，2个疗程后统计疗效，并观察2组心绞痛发作情况、硝酸甘油用量及治疗前后血浆hs-CRP、TNF-α及sFas水平的变化。结果治疗组总有效率87．10％，对照组总有效率75．81％，2组总有效率比较差异有统计学意义（P＜0．05），治疗组疗效优于对照组。治疗组治疗后心绞痛发作次数、发作间隔及持续时间均低于对照组（P＜0．05）。2组硝酸甘油日均用量均减少（P＜0．05），治疗组治疗后硝酸甘油日均用量低于对照组（P＜0．05）。治疗组治疗后hs-CRP、TNF-α、sFas与本组治疗前比较均降低（P＜0．05）。2组治疗后hs-CRP、TNF-α、sFas比较差异均有统计学意义（P＜0．05），治疗组低于对照组。结论注射液用丹参多酚酸盐治疗UAP疗效确切，且能够抑制炎症反应和细胞凋亡。
目的：觀察註射用丹參多酚痠鹽對不穩定性心絞痛（ UAP）患者血漿高敏C反應蛋白（ hs-CRP）、腫瘤壞死因子（TNF-α）以及可溶性細胞凋亡因子Fas（sFas）的影響。方法將124例UAP患者隨機分為2組。對照組62例予西醫常規治療，治療組62例在對照組治療基礎上加用註射用丹參多酚痠鹽治療。2組均14 d為1箇療程，2箇療程後統計療效，併觀察2組心絞痛髮作情況、硝痠甘油用量及治療前後血漿hs-CRP、TNF-α及sFas水平的變化。結果治療組總有效率87．10％，對照組總有效率75．81％，2組總有效率比較差異有統計學意義（P＜0．05），治療組療效優于對照組。治療組治療後心絞痛髮作次數、髮作間隔及持續時間均低于對照組（P＜0．05）。2組硝痠甘油日均用量均減少（P＜0．05），治療組治療後硝痠甘油日均用量低于對照組（P＜0．05）。治療組治療後hs-CRP、TNF-α、sFas與本組治療前比較均降低（P＜0．05）。2組治療後hs-CRP、TNF-α、sFas比較差異均有統計學意義（P＜0．05），治療組低于對照組。結論註射液用丹參多酚痠鹽治療UAP療效確切，且能夠抑製炎癥反應和細胞凋亡。
목적：관찰주사용단삼다분산염대불은정성심교통（ UAP）환자혈장고민C반응단백（ hs-CRP）、종류배사인자（TNF-α）이급가용성세포조망인자Fas（sFas）적영향。방법장124례UAP환자수궤분위2조。대조조62례여서의상규치료，치료조62례재대조조치료기출상가용주사용단삼다분산염치료。2조균14 d위1개료정，2개료정후통계료효，병관찰2조심교통발작정황、초산감유용량급치료전후혈장hs-CRP、TNF-α급sFas수평적변화。결과치료조총유효솔87．10％，대조조총유효솔75．81％，2조총유효솔비교차이유통계학의의（P＜0．05），치료조료효우우대조조。치료조치료후심교통발작차수、발작간격급지속시간균저우대조조（P＜0．05）。2조초산감유일균용량균감소（P＜0．05），치료조치료후초산감유일균용량저우대조조（P＜0．05）。치료조치료후hs-CRP、TNF-α、sFas여본조치료전비교균강저（P＜0．05）。2조치료후hs-CRP、TNF-α、sFas비교차이균유통계학의의（P＜0．05），치료조저우대조조。결론주사액용단삼다분산염치료UAP료효학절，차능구억제염증반응화세포조망。
Objective To observe the effect of salvianolate injection on plasma high -sensitivity c-reactive protein( hs-CRP) and tumor necrosis factor ( TNF-α) and soluble cell apoptosis factor ( sFas) in unstable angina patients(UAP).Methods 124 patients with UAP were randomly divided into 2 groups.Control group of 62 cases received conventional western medicine treatment ,62 cases in the treatment group received salvianolate on the basis of control group treatment .14 days was as a period of treatment .The therapeutic effect was evaluated after two courses . The changes of hs -CRP,TNF-αlpha and sFas,anginal frequency and nitroglycerin consumption were observed .Re-sults The total effective rate in treatment group was 87.10%.The total effective rate in control group was 75.81%. There was significant difference between two groups on the total effective rate (P<0.05).Angina attack frequency, episodes interval and duration in treatment group was lower than that in control group (P<0.05).The daily average volume of nitroglycerin in two groups was decreased (P<0.05),the average daily dosage of nitroglycerin in treatment group was lower than that in the control group (P<0.05).The levels of hs-CRP,TNF-αand sFas after treatment were decreased as compared with those before treatment in treatment group (P<0.05).There was significant differ-ence between two groups on the levels of hs -CRP,TNF-αand sFas after treatment (P<0.05).Conclusion Salvianolate injection can inhibit inflammatory reaction and apoptosis in the treatment of unstable angina patients .
