CAJ | 학술논문

目的：探讨人乳头瘤病毒（ HPV）16/18与下咽鳞癌及其颈部淋巴结转移的关系。方法应用原位杂交（ ISH）技术检测20例下咽癌组织及其颈部淋巴结组织中HPV16/18 DNA的表达情况，并结合病人临床资料进行回顾性分析。结果20例下咽组织中检出HPV16/18 DNA阳性2例占10．0％，12例转移性颈部淋巴结标本中检出 HPV16/18 DNA 阳性1例占8．3％，颈部正常淋巴结中均未检出 HPV16/18 DNA。3例HPV16/18阳性病例均为临床Ⅳ期下咽鳞癌病例。结论 HPV16/18在下咽鳞癌及其颈部转移性淋巴结中的检出率较低。
목적：탐토인유두류병독（ HPV）16/18여하인린암급기경부림파결전이적관계。방법응용원위잡교（ ISH）기술검측20례하인암조직급기경부림파결조직중HPV16/18 DNA적표체정황，병결합병인림상자료진행회고성분석。결과20례하인조직중검출HPV16/18 DNA양성2례점10．0％，12례전이성경부림파결표본중검출 HPV16/18 DNA 양성1례점8．3％，경부정상림파결중균미검출 HPV16/18 DNA。3례HPV16/18양성병례균위림상Ⅳ기하인린암병례。결론 HPV16/18재하인린암급기경부전이성림파결중적검출솔교저。
Objective To explore the correlation of human papillomavirus ( HPV) 16/18 with hypopharyngeal squamous cell carcinoma ( HPSCC ) and associated cervical lymph node metastases .Methods Hybridization in situ ( ISH) was used to detect the expression of HPV 16/18 DNA in the tumor tissues and associated cervical lymph nodes of 20 patients with HPSCC.The clinical data was retrospectively analyzed .Results Among 20 samples of tumor tissues of HPSCC,there were 2 with positive HPV16/18 DNA which accounted for 10.0%.Among 12 samples of cervical lymph node metastases of HPSCC,there were 1 with positive HPV16/18 DNA which accounted for 8.3%.There was no HPV16/18 DNA detected in normal lymph nodes .The 3 cases of positive HPV16/18 were HPSCC of stageⅣ.Conclusion HPV16/18 might be of low expression in HPSCC and associated cervical lymph node metastases .