CAJ | 학술논문

目的：观察小针刀疗法对膝关节骨性关节炎（ KOA）患者关节液肿瘤坏死因子-α（ TNF-α）及一氧化氮（ NO）表达的影响，探讨小针刀的作用机制。方法将120例KOA患者随机分为2组。治疗组60例采用小针刀治疗，对照组60例采用普通针刺治疗。6周后检测比较2组患者治疗前后关节液中TNF-α及NO的水平，同时评定临床疗效。结果2组治疗后关节液中TNF-α及NO水平均较本组治疗前降低（ P＜0．05，P＜0．01），且治疗组下降更为明显（P＜0．01）。2组治疗后症状均有不同程度的改善，治疗组总有效率（78．3％）优于对照组（71．7％）（P＜0．05）。结论小针刀疗法治疗KOA比常规毫针刺法更有效。
목적：관찰소침도요법대슬관절골성관절염（ KOA）환자관절액종류배사인자-α（ TNF-α）급일양화담（ NO）표체적영향，탐토소침도적작용궤제。방법장120례KOA환자수궤분위2조。치료조60례채용소침도치료，대조조60례채용보통침자치료。6주후검측비교2조환자치료전후관절액중TNF-α급NO적수평，동시평정림상료효。결과2조치료후관절액중TNF-α급NO수평균교본조치료전강저（ P＜0．05，P＜0．01），차치료조하강경위명현（P＜0．01）。2조치료후증상균유불동정도적개선，치료조총유효솔（78．3％）우우대조조（71．7％）（P＜0．05）。결론소침도요법치료KOA비상규호침자법경유효。
Objective To observe the effect of small needle knife therapy on tumor necrosis factor -α( TNF-α) and nitric oxide ( NO) in synovial fluid of patients with knee osteoarthritis ( KOA) and to study the effect and mechanism of small needle knife .Methods 120 patients with KOA were randomly divided into treatment group and control group with 60 cases in each .The 60 patients in treatment group were treated with little needle knife ,60 ca-ses in the control group were treated by normal acupuncture treatment .After 6 weeks of treatment TNF -αand NO levels of in the synovial fluid before and after treatment were compared in the two groups ,and the clinical efficacy was assessed.Results TNF-αand NO levels of in the synovial fluid after treatment were decreased as compared with those before treatment in the two groups (P<0.05,P<0.01).The decrease in treatment group was obvious (P<0.01).Symptoms were improved after treatment in two groups ,The improvement in the treatment group was better than that in control group ( P<0.05) .Conclusion The small needle knife therapy in the treatment of KOA is more effective than conventional acupuncture .