CAJ | 학술논문

目的：探讨苗药痛风停汤对急性痛风性关节炎模型大鼠白细胞介素-8的影响。方法：将48只雌性SD大鼠随机分为空白对照组、模型对照组、痛风停治疗组及双氯芬酸钠对照组，每组12只。复制急性痛风性关节炎大鼠模型，采用光镜观察模型大鼠关节病理变化，酶联免疫吸附（ELISA）法检测大鼠血清白细胞介素-8。结果：模型对照组、痛风停治疗组、双氯芬酸钠对照组白细胞介素-8的表达均高于空白对照组（P<0.01）；与模型对照组比较，痛风停治疗组、双氯芬酸钠对照组白细胞介素-8的水平较低（P<0.01）。结论：痛风停汤能够降低急性痛风性关节炎SD大鼠白细胞介素-8的表达，减轻关节滑膜炎症。
목적：탐토묘약통풍정탕대급성통풍성관절염모형대서백세포개소-8적영향。방법：장48지자성SD대서수궤분위공백대조조、모형대조조、통풍정치료조급쌍록분산납대조조，매조12지。복제급성통풍성관절염대서모형，채용광경관찰모형대서관절병리변화，매련면역흡부（ELISA）법검측대서혈청백세포개소-8。결과：모형대조조、통풍정치료조、쌍록분산납대조조백세포개소-8적표체균고우공백대조조（P<0.01）；여모형대조조비교，통풍정치료조、쌍록분산납대조조백세포개소-8적수평교저（P<0.01）。결론：통풍정탕능구강저급성통풍성관절염SD대서백세포개소-8적표체，감경관절활막염증。
Objective:To investigate the effects of Miao medicine Tongfengting Decoction on the serum IL-8 in model rats with acute gouty arthritis.Methods:48 female SD rats were randomly and equally divided into the blank control group,the model control group,the Tongfengting control group and the diclofenac sodium control group.Duplicated the rat models with acute gouty arthritis and observed the pathological changes of rat models with optical microscope. The enzyme linked immunosorbent assay (ELISA) was used to detect the serum IL-8 in model rats.Results:The expressions of IL-8 in the model control group,the Tongfengting group and the diclofenac sodium control group were higher than that of the blank control group (P<0.01);compared with the model control group,the IL-8 level in the Tongfengting control group and the diclofenac sodium control group was lower (P<0.01).Conclusion:Tongfengting Decoction can decrease the expression of IL-8 in SD rats with acute gouty arthritis,alleviating the inlfammation of joint synovium.