重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
1期
77-79,82
,共4页
瞿星光%张朝晖%周刚%龚勋%张蓉%曾超%李灵丰%钟建华%姚玲
瞿星光%張朝暉%週剛%龔勛%張蓉%曾超%李靈豐%鐘建華%姚玲
구성광%장조휘%주강%공훈%장용%증초%리령봉%종건화%요령
重症急性胰腺炎%生长抑素%前列腺素E1%联合治疗
重癥急性胰腺炎%生長抑素%前列腺素E1%聯閤治療
중증급성이선염%생장억소%전렬선소E1%연합치료
severe acute pancreatitis%somatostatin%prostaglandin E1%combined therapy
目的:观察生长抑素(SS)和前列腺素E1(PGE1)联合应用对重症急性胰腺炎(SAP)的临床效果,探讨两者联合应用的作用机制。方法将收治的31例SAP的患者分为对照组(SS治疗组,n=15)和联合治疗组(SS+ PGE1组,n=16),于入院后第1、4、7天检测外周血内毒素、肿瘤坏死因子-α(TNF-α)、IL-6、IL-10及CRP的变化;监测血小板(PLT)、凝血酶凝结时间(TT)、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、纤维蛋白原(FIB)和D-二聚体;检测血清淀粉酶和乳酸脱氢酶和清蛋白;观察ICU入住时间、治疗14 d后APACHEⅡ评分、Binder积分、中转手术率、28 d病死率。结果与对照组比较,联合治疗组于治疗7、14 d后上述临床及实验室检测指标均有改善,差异有统计学意义(P<0.05)。结论 SS和PGE1联合应用可显著改善SAP患者的预后,缩短IC U入住时间,降低28 d病死率,其可能的作用机制是减轻急性期炎症介质和细胞因子的过度释放,提高机体免疫能力等多层次,改善胰腺的微循环,纠正高凝状态,避免SAP患者并发多器官功能障碍。
目的:觀察生長抑素(SS)和前列腺素E1(PGE1)聯閤應用對重癥急性胰腺炎(SAP)的臨床效果,探討兩者聯閤應用的作用機製。方法將收治的31例SAP的患者分為對照組(SS治療組,n=15)和聯閤治療組(SS+ PGE1組,n=16),于入院後第1、4、7天檢測外週血內毒素、腫瘤壞死因子-α(TNF-α)、IL-6、IL-10及CRP的變化;鑑測血小闆(PLT)、凝血酶凝結時間(TT)、凝血酶原時間(PT)、活化部分凝血活酶時間(APTT)、纖維蛋白原(FIB)和D-二聚體;檢測血清澱粉酶和乳痠脫氫酶和清蛋白;觀察ICU入住時間、治療14 d後APACHEⅡ評分、Binder積分、中轉手術率、28 d病死率。結果與對照組比較,聯閤治療組于治療7、14 d後上述臨床及實驗室檢測指標均有改善,差異有統計學意義(P<0.05)。結論 SS和PGE1聯閤應用可顯著改善SAP患者的預後,縮短IC U入住時間,降低28 d病死率,其可能的作用機製是減輕急性期炎癥介質和細胞因子的過度釋放,提高機體免疫能力等多層次,改善胰腺的微循環,糾正高凝狀態,避免SAP患者併髮多器官功能障礙。
목적:관찰생장억소(SS)화전렬선소E1(PGE1)연합응용대중증급성이선염(SAP)적림상효과,탐토량자연합응용적작용궤제。방법장수치적31례SAP적환자분위대조조(SS치료조,n=15)화연합치료조(SS+ PGE1조,n=16),우입원후제1、4、7천검측외주혈내독소、종류배사인자-α(TNF-α)、IL-6、IL-10급CRP적변화;감측혈소판(PLT)、응혈매응결시간(TT)、응혈매원시간(PT)、활화부분응혈활매시간(APTT)、섬유단백원(FIB)화D-이취체;검측혈청정분매화유산탈경매화청단백;관찰ICU입주시간、치료14 d후APACHEⅡ평분、Binder적분、중전수술솔、28 d병사솔。결과여대조조비교,연합치료조우치료7、14 d후상술림상급실험실검측지표균유개선,차이유통계학의의(P<0.05)。결론 SS화PGE1연합응용가현저개선SAP환자적예후,축단IC U입주시간,강저28 d병사솔,기가능적작용궤제시감경급성기염증개질화세포인자적과도석방,제고궤체면역능력등다층차,개선이선적미순배,규정고응상태,피면SAP환자병발다기관공능장애。
Objective To study the effect of somatostatin(SS) combined with prostaglandin E1 (PGE1) in patients with severe acute pancreatits (SAP) and to elucidate its underlying mechanisms .Methods 31 cases of SAP patients were randomly divided into control group (SS group ,n=15) and combined treatment group (group SS+ PGE1 ,n=16) .On the first ,4th ,7th day after admis-sion ,the peripheral blood endotoxin ,TNF-α,IL-6 ,IL-10 and CRP changes of patients in two groups were detected ;PLT ,TT ,PT , APTT ,FIB and D two dimer were monitored ;serum amylase and lactate dehydrogenase (LDH ) and serum albumin (ALB ) were detected ;and ICU occupancy time ,after 14 d treatment APACHE Ⅱ ,Binder integral ,transit operation rate ,the mortality of 28 d were also observed .Results Compared with control group ,the treatment group for the treatment of 7 ,14 days after the clinical and laboratory parameters were improved ,and there were significant difference .Conclusion SS and PGE1 combination can significantly improve the prognosis of patients with SAP ,reduce ICU inpatient time and the mortality of 28 d ,its possible mechanism of action would be to reduce acute phase inflammatory mediators and the release of cytokines ,improve the immunity of the organism ,multi-level ,improve the pancreatic microcirculation ,correct the hypercoagulable state ,and avoid complications of multiple organ dysfunc-tion in SAP patients .