重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2014年
1期
27-29
,共3页
宫颈癌%骨桥蛋白%TP化疗方案%疗效评价
宮頸癌%骨橋蛋白%TP化療方案%療效評價
궁경암%골교단백%TP화료방안%료효평개
cervical carcinoma%OPN%TP chemotherapy%therapeutic evaluation
目的：检测宫颈癌患者化疗前后骨桥蛋白（O PN ）表达水平，探讨其在化疗疗效评价中的临床价值。方法对90例宫颈鳞癌患者采用TP化疗方案治疗，通过免疫组化法对化疗前后OPN表达情况进行检测，研究OPN在宫颈癌化疗疗效评价中的意义。结果化疗前组织中OPN表达阳性率为85．56％，化疗后为62．22％，化疗前后OPN表达阳性率差异有统计学意义（χ2＝14．118，P＜0．05）；化疗有效组化疗前OPN表达阳性率为78．69％，化疗后为47．54％，化疗前后差异有统计学意义（χ2＝20．840，P＜0．05）；化疗无效者化疗前O PN表达阳性率为100．00％，化疗后为96．56％，化疗前后差异无统计学意义（χ2＝3．046， P＞0．05）。OPN表达阴性的患者完全缓解（CR）率为100％（13/13），OPN表达阳性的患者CR率为45．46％（35/77），两组相比差异有统计学意义（P＜0．05）。结论 OPN在宫颈癌组织中表达水平与化疗的效果及肿瘤对化疗药物的敏感性有关。
目的：檢測宮頸癌患者化療前後骨橋蛋白（O PN ）錶達水平，探討其在化療療效評價中的臨床價值。方法對90例宮頸鱗癌患者採用TP化療方案治療，通過免疫組化法對化療前後OPN錶達情況進行檢測，研究OPN在宮頸癌化療療效評價中的意義。結果化療前組織中OPN錶達暘性率為85．56％，化療後為62．22％，化療前後OPN錶達暘性率差異有統計學意義（χ2＝14．118，P＜0．05）；化療有效組化療前OPN錶達暘性率為78．69％，化療後為47．54％，化療前後差異有統計學意義（χ2＝20．840，P＜0．05）；化療無效者化療前O PN錶達暘性率為100．00％，化療後為96．56％，化療前後差異無統計學意義（χ2＝3．046， P＞0．05）。OPN錶達陰性的患者完全緩解（CR）率為100％（13/13），OPN錶達暘性的患者CR率為45．46％（35/77），兩組相比差異有統計學意義（P＜0．05）。結論 OPN在宮頸癌組織中錶達水平與化療的效果及腫瘤對化療藥物的敏感性有關。
목적：검측궁경암환자화료전후골교단백（O PN ）표체수평，탐토기재화료료효평개중적림상개치。방법대90례궁경린암환자채용TP화료방안치료，통과면역조화법대화료전후OPN표체정황진행검측，연구OPN재궁경암화료료효평개중적의의。결과화료전조직중OPN표체양성솔위85．56％，화료후위62．22％，화료전후OPN표체양성솔차이유통계학의의（χ2＝14．118，P＜0．05）；화료유효조화료전OPN표체양성솔위78．69％，화료후위47．54％，화료전후차이유통계학의의（χ2＝20．840，P＜0．05）；화료무효자화료전O PN표체양성솔위100．00％，화료후위96．56％，화료전후차이무통계학의의（χ2＝3．046， P＞0．05）。OPN표체음성적환자완전완해（CR）솔위100％（13/13），OPN표체양성적환자CR솔위45．46％（35/77），량조상비차이유통계학의의（P＜0．05）。결론 OPN재궁경암조직중표체수평여화료적효과급종류대화료약물적민감성유관。
Objective To detect osteopontin (OPN) expression level of cervical cancer patients before and after chemotherapy , and explore the clinical value in the evaluation of chemotherapy efficacy .Methods 90 cases of cervical squamous cell carcinoma were treated with TP regimen ,immunohistochemical method was used to detect OPN expression before and after chemotherapy ,and studied the significance of OPN evaluation on curative effect in cancer chemotherapy .Results Before chemotherapy the positive ex-pression rate of OPN of tissue was 85 .56% ,and that after chemotherapy was 62 .22% ,the positive rate of OPN expression has sig-nificant difference before and after chemotherapy conclusion(χ2 =14 .118 ,P<0 .05) .The positive expression rate of OPN of effec-tive chemotherapy group before chemotherapy was 78 .69% ,and that after chemotherapy was 47 .54% ,there were significant differ-ences(χ2 =20 .840 ,P<0 .05) .Before chemotherapy ,the positive expression rate of OPN in ineffective chemotherapy was 100% ,af-ter chemotherapy ,it was 96 .56% ,there were no significant difference(χ2 =3 .046 ,P>0 .05) .Patients with OPN negative expres-sion rate of CR was 100% (13/13) ,OPN patients with positive expression rate of CR was 45 .46% (35/77) ,compared two groups with statistical difference (P<0 .05) .Conclusion The expression of OPN in cervical cancer tissue in the tumor is related with chemotherapy sensitivity and effect of chemotherapy .
