CAJ | 학술논문

目的：探讨肺癌荷瘤小鼠体内炎性微环境中 IL-6、IL-8、NF-KB 和 TNF-α的变化情况。方法：选用雄性 C57小黑鼠24只,随机分成正常组和肿瘤组,每组12只。肿瘤组接种 Lewis 肺癌,正常组不做处理,待肿瘤直径达到0.5~1cm 后,分别于第7天、第14天各组各处死6只 C57小鼠,取其血清,ELISA 法检测 NF-KB、TNF-a、IL-6、IL-8。结果：肿瘤组的肿瘤相关炎性因子 NF-KB、TNF-a、IL-6、IL-8明显高于正常组,差异具有显著统计学意义(P <0.05)。结论：肺癌荷瘤小鼠体内促进肿瘤生长的炎性因子明显升高,炎性因子有望成为肺癌筛查及诊治效果评价的新指标。
목적：탐토폐암하류소서체내염성미배경중 IL-6、IL-8、NF-KB 화 TNF-α적변화정황。방법：선용웅성 C57소흑서24지,수궤분성정상조화종류조,매조12지。종류조접충 Lewis 폐암,정상조불주처리,대종류직경체도0.5~1cm 후,분별우제7천、제14천각조각처사6지 C57소서,취기혈청,ELISA 법검측 NF-KB、TNF-a、IL-6、IL-8。결과：종류조적종류상관염성인자 NF-KB、TNF-a、IL-6、IL-8명현고우정상조,차이구유현저통계학의의(P <0.05)。결론：폐암하류소서체내촉진종류생장적염성인자명현승고,염성인자유망성위폐암사사급진치효과평개적신지표。
To investigate the changes of inflammatory microenvironment in which IL-6,IL-8,NF-KB and TNF-αfor mice bearing lung cancer.Methods:24 male C57 mice,were randomly divided into two groups:normal group and tumor group,12 rats in each group.Tumor group was with Lewis lung cancer,normal group was not treated. When tumor diameter reach 0.5~1cm,we detected the serum NF-KB,TNF-a,IL-6 and IL-8 using ELISA method.Re-sults:Tumor associated inflammatory factors NF-KB,TNF-a,IL-6,IL-8 in the tumor group was significantly higher than the normal group,the difference was statistically significant (P <0.05).Conclusion:Inflammatory factors promote lung cancer growth significantly.Inflammatory factors are expected to become a new marker for lung cancer screening and diagnosis.