CAJ | 학술논문

目的：研究Bcl-2和Bax在结膜松弛症患者的结膜组织中的表达状况。 　　方法：HE染色观察松弛结膜组织的组织特点，免疫组织化学方法检测20例结膜松弛症患者松弛结膜组织中Bcl-2和Bax的表达状况，并与10例正常结膜组织进行比较。 　　结果：松弛结膜组织鳞状上皮增生间质中有淋巴、浆细胞浸润，Bcl-2在松弛结膜组织中表达与对照组比较差别无显著性意义（P＞0．05），Bax在松弛结膜组织中表达明显增加，与对照组比较差别有显著性意义（P＜0．05），经Spearman等级相关分析（ r＝0．432， P＞0．05）， Bcl-2与Bax阳性表达间无相关性。 　　结论：Bcl-2和Bax表达失衡可能在结膜松弛症的发生和发展中起着重要的作用。
목적：연구Bcl-2화Bax재결막송이증환자적결막조직중적표체상황。 　　방법：HE염색관찰송이결막조직적조직특점，면역조직화학방법검측20례결막송이증환자송이결막조직중Bcl-2화Bax적표체상황，병여10례정상결막조직진행비교。 　　결과：송이결막조직린상상피증생간질중유림파、장세포침윤，Bcl-2재송이결막조직중표체여대조조비교차별무현저성의의（P＞0．05），Bax재송이결막조직중표체명현증가，여대조조비교차별유현저성의의（P＜0．05），경Spearman등급상관분석（ r＝0．432， P＞0．05）， Bcl-2여Bax양성표체간무상관성。 　　결론：Bcl-2화Bax표체실형가능재결막송이증적발생화발전중기착중요적작용。
AIM: To study expression of Bcl -2 and Bax in conjunctival tissue samples of conjunctivochalasis patients. METHODS:To observe the histopathological change of conjunctivochalasis by HE staining of conjunctival tissue. Immunohistochemical staining was applied to compare the expression situation of Bcl-2 and Bax in conjunctival tissue of conjunctivochalasis patient ( 20 samples ) and the normal conjunctiva tissue (10 samples). RESULTS: There were lymphocyte and plasmocyte infiltration in the conjunctivochalasis tissue. The expression of Bcl -2 in the conjunctivochalasis was similar with the normal conjunctiva tissue (P>0.05).The expression of Bax in the two tissues showed significant difference (P<0.05).Spearman rank correlation analysis ( r =0.432, P >0.05 ) indicated that there was no correlation between the expression of Bcl-2 and Bax. CONCLUSION: Unbalanced expression of Bcl-2 and Bax in conjunctival tissue may play a significant role in the occurrence and development of conjunctivochalasis.