CAJ | 학술논문

目的：利用磁共振扩散张量成像（diffusion tensor imaging， DTI ）技术研究单眼弱视儿童治疗前后视放射的变化及其神经机制。 　　方法：选择18例左眼屈光参差性弱视儿童经过为期9 mo的弱视治疗，对治疗前后的视放射进行DTI检查，比较分析治疗前后视放射的各向异性分数（ fractional anisotropy ， FA）值和表观扩散系数（ apparent diffusion coefficient ， ADC）值的变化。 　　结果：治疗后两侧视放射的FA 值均高于治疗前（ P＜0.05），ADC值均低于治疗前（P＜0．05）。右侧视放射治疗前后FA值和ADC值的变化均大于左侧视放射（ P＜0.05）。 　　结论：单眼弱视儿童经过有效的弱视治疗后，两侧视放射的神经纤维均得到不同程度的改善。
목적：이용자공진확산장량성상（diffusion tensor imaging， DTI ）기술연구단안약시인동치료전후시방사적변화급기신경궤제。 　　방법：선택18례좌안굴광삼차성약시인동경과위기9 mo적약시치료，대치료전후적시방사진행DTI검사，비교분석치료전후시방사적각향이성분수（ fractional anisotropy ， FA）치화표관확산계수（ apparent diffusion coefficient ， ADC）치적변화。 　　결과：치료후량측시방사적FA 치균고우치료전（ P＜0.05），ADC치균저우치료전（P＜0．05）。우측시방사치료전후FA치화ADC치적변화균대우좌측시방사（ P＜0.05）。 　　결론：단안약시인동경과유효적약시치료후，량측시방사적신경섬유균득도불동정도적개선。
AIM: To investigate the alterations of optic radiations ( ORs ) in monocular amblyopic children underwent treatment by using diffusion tensor imaging ( DTI ) , and to explore its underlying neuromechanism. METHODS: Eighteen children with anisometropic amblyopia ( all left eyes ) were recruited for amblyopia therapy.DTI data of ORs were acquired for each patient twice: before and after 9mo amblyopia therapy. The fractional anisotropy ( FA) values and apparent diffusion coefficient ( ADC ) values were campared between the previous and posterior scans. RESULTS: On both sides of ORs, the FA values of posterior therapy were higher than those of previous therapy ( P<0.05 ), while the ADC values of posterior therapy were lower than those of previous therapy ( P<0.05).The alterations of FA values and ADC values of ORs on the right side were greater than those of ORs on the left side after therapy (P<0.05). CONCLUSION: Both sides of ORs in monocular amblyopic children are modified to varying degrees after myopia therapy.