CAJ | 학술논문

目的：研究在马来西亚非青光眼视神经萎缩的病因及临床特点。 　　方法：一系列回顾性的研究分析马来西亚理科大学校医院眼诊所在2007/2011年间被诊断为非青光眼视神经萎缩的患者。至少随访1a。评估这些患者的医疗记录及汇编调查结果。 　　结果：100例患者符合选择标准，56％的患者双眼都参与研究。主要症状为视力模糊（61％），除了视力模糊外还出现神经方面病症（18％），视野狭窄（9％）。大多数患者（63％）患眼视力下降到3/60以下。主要的病因是颅内占位性病变（26％），先天性疾病（13％），脑积水（12％），创伤（12％）及血管因素（12％）。对大多数患者（67％）采用保守治疗。不管其病因，视神经萎缩都伴有不同程度的视功能障碍。随访1 a后，50％的患者出现不同程度的视觉障碍。 　　结论：视神经萎缩主要的病因是颅内占位性病变，其次分别是先天性疾病，创伤和血管疾病。在诊断之前常常就出现视觉和神经上的症状，而疾病显著地影响着视力的变化。为了早期诊断视神经萎缩，当视力模糊的主诉为非特异性时，应该高度怀疑本病。
목적：연구재마래서아비청광안시신경위축적병인급림상특점。 　　방법：일계렬회고성적연구분석마래서아이과대학교의원안진소재2007/2011년간피진단위비청광안시신경위축적환자。지소수방1a。평고저사환자적의료기록급회편조사결과。 　　결과：100례환자부합선택표준，56％적환자쌍안도삼여연구。주요증상위시력모호（61％），제료시력모호외환출현신경방면병증（18％），시야협착（9％）。대다수환자（63％）환안시력하강도3/60이하。주요적병인시로내점위성병변（26％），선천성질병（13％），뇌적수（12％），창상（12％）급혈관인소（12％）。대대다수환자（67％）채용보수치료。불관기병인，시신경위축도반유불동정도적시공능장애。수방1 a후，50％적환자출현불동정도적시각장애。 　　결론：시신경위축주요적병인시로내점위성병변，기차분별시선천성질병，창상화혈관질병。재진단지전상상취출현시각화신경상적증상，이질병현저지영향착시력적변화。위료조기진단시신경위축，당시력모호적주소위비특이성시，응해고도부의본병。
AIM:To describe the aetiology and clinical profile of non-glaucomatous optic atrophy in a tertiary hospital in M alaysia. METHODS: A retrospective case series was conducted on patients diagnosed with non -glaucomatous optic atroph y who presented to the Eye Clinic of Hospital Universiti Sains Malaysia from 2007 until 2011 with a minimum of one year follo w-up.Medical records of these patients were reviewed and the findings compiled. RESULT S: Of the 100 patients who met th e selection criteria, 56% had bilateral involvement. The chief presentingsymptom was visual blurring (61%), followed by v isual blurring with neurological symptoms (18%) and visual field constriciton (9%).Most patients (63%) had a presenting vi sual acuity worse than 3/60 in the affected eye. The main aetiologies were space -occupying intracranial lesions (26%), con genital/hereditary diseases ( 13%) , hydrocephalus ( 12%) , trauma ( 12%) , and vascular causes ( 12%) . The majority of c ases ( 67%) were managed conservatively.Regardless of aetiology, optic atrophy was associated with variable degrees of visual dysfunction.At the end of one year, 50% of the patients had some degree of visual impairment. CONCLUSION:The main aetiology of optic atrophy was space -occupying intracranial lesions, followed by congenital/hereditary, trauma and vascular problems. Visual or neurological symptoms usually preceded the diagnosis, and visual acuity was significantly affected by the disease.A high level of suspicion is required in order to make an early diagnosis of optic atrophy, as the main complaint of visual blurring is usually non-specific.